Reactome | CSF3R binds CSF3 dimer

CSF3R binds CSF3 dimer

Stable Identifier

R-HSA-6787737

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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The granulocyte colony-stimulating factor receptor (CSF3R, GCSFR, CD114) is a cell-surface receptor for the granulocyte colony-stimulating factor (CSF3, GCSF) (Larsen et al. 1990, Panopoulos & Watowich 2008). It is present on precursor cells in the bone marrow. CSF3 initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.

CSF3 exists as a dimer and higher order oligomeric structures; only the dimer exhibits high affinity binding (Hiraoka & Anaguchi et al. 1994). CSF3R ligand-binding is associated with dimerization of the receptor (Aritomi et al. 1999, Tamada et al. 2006, Layton & Hall 2006) and signal transduction through Jak/STAT, Lyn and Erk1/2. Mutations in CSF3R are a cause of Kostmann syndrome, also known as severe congenital neutropenia (Zeidler & Welte 2002, Vandenberghe & Beel 2011).

Literature References

PubMed ID	Title	Journal	Year
7805849	Evidence for the ligand-induced conversion from a dimer to a tetramer of the granulocyte colony-stimulating factor receptor Hiraoka, O, Anaguchi, H, Ota, Y	FEBS Lett.	1994
2147944	Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains Larsen, A, Davis, T, Curtis, BM, Gimpel, S, Sims, JE, Cosman, D, Park, L, Sorensen, E, March, CJ, Smith, CA	J. Exp. Med.	1990