DDHD1,2 hydrolyse PA

Stable Identifier
Reaction [transition]
Homo sapiens
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Glycerophospholipids are important structural and functional components of biological membranes, of serum lipoproteins and pulmonary surfactant and act as precursors of lipid mediators such as platelet-activating factor and eicosanoids. Phosphatidic acid (PA) is a common glycerophospholipid and its hydrolysis can mediate its functions described above. Phospholipases DDHD1 and 2 can mediate the hydrolysis of PA (Inoue et al. 2012, Nakajima et al. 2002). Defects in DDHD1 or DDHD2 can cause autosomal recessive spastic paraplegias 28 or 54 respectively (SPG28, MIM:609340; SPG54, MIM:615033). These are forms of neurodegenerative spastic paraplegia, characterised by slow, gradual, progressive weakness and spasticity of the lower limbs (Tesson et al. 2012, Schuurs-Hoeijmakers et al. 2012).

Literature References
PubMed ID Title Journal Year
11788596 A novel phospholipase A1 with sequence homology to a mammalian Sec23p-interacting protein, p125

Tagaya, M, Sonoda, H, Nakajima, K, Mizoguchi, T, Tani, K, Arai, H, Nagahama, M, Aoki, J

J. Biol. Chem. 2002
23176823 Mutations in DDHD2, encoding an intracellular phospholipase A(1), cause a recessive form of complex hereditary spastic paraplegia

Kamsteeg, EJ, Otte-Höller, I, Geraghty, MT, Ben-Salem, S, Vermeer, S, Humphreys, P, Nobau, AC, Schwartzentruber, J, van de Vondervoort, II, de Bot, ST, Schuurs-Hoeijmakers, JH, van der Graaf, M, Smith, AC, Nijhof, B

Am. J. Hum. Genet. 2012
23176821 Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia

Tesson, C, Yamashita, A, Gaussen, M, Nawara, M, Elmalik, SA, Zaki, MS, Al Abdulkareem, I, Al Drees, A, Durr, A, Benomar, A, Darios, F, Mochel, F, Al Balwi, M, Lechner, D, Lacombe, D, Schols, L, Yahyaoui, M, Goizet, C, Depienne, C, Esteves, T, Oteyza, AC, Gonzalez, M, Salih, MA, Lamari, F, Monin, ML, Obre, E, Durand, CM, Gyapay, G, Gleeson, JG, Kabiraj, MM, Bouslam, N, Schule, R, Bouhouche, A, Brice, A, Zuchner, S, El-Hachimi, KH, Santorelli, FM, Seidahmed, MZ, Rossignol, R, Lavie, J, Stevanin, G, Mignot, C

Am. J. Hum. Genet. 2012
22922100 Roles of SAM and DDHD domains in mammalian intracellular phospholipase A1 KIAA0725p

Tagaya, M, Inoue, H, Sato, S, Tani, K, Ohtsuki, R, Watanabe, T, Baba, T, Takemori, A

Biochim. Biophys. Acta 2012
Catalyst Activity

phospholipase activity of DDHD1,2 [cytosol]

Orthologous Events
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