FANCD2 deubiquitination by USP1:WDR48

Stable Identifier
R-HSA-6786171
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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The FA pathway is negatively regulated through the USP1:WDR48-mediated deubiquitination of FANCD2 (Nijman et al. 2005). WDR48 (UAF1) forms a complex with and activates USP1 (Cohn et al. 2007).

Literature References
PubMed ID Title Journal Year
18082604 A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway

Cohn, MA, Kowal, P, Yang, K, Haas, W, Huang, TT, Gygi, SP, D'Andrea, AD

Mol Cell 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of USP1:WDR48 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created