The FA pathway is negatively regulated through the USP1:WDR48-mediated deubiquitination of FANCD2 (Nijman et al. 2005). WDR48 (UAF1) forms a complex with and activates USP1 (Cohn et al. 2007).
thiol-dependent ubiquitin-specific protease activity of USP1:WDR48 [nucleoplasm]