POLN binds ICL-DNA

Stable Identifier
R-HSA-6786155
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
POLN binds ICL-DNA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

An error-prone DNA polymerase nu (POLN) is recruited to the interstrand crosslink (ICL) repair site through interaction with monoubiquitinated FANCD2 and probably the PCNA subunit of the stalled replication complex (Moldovan et al. 2010).

Literature References
PubMed ID Title Journal Year
19995904 DNA polymerase POLN participates in cross-link repair and homologous recombination

Moldovan, GL, Madhavan, MV, Vinciguerra, P, McCaffrey, RM, Mirchandani, KD, D'Andrea, AD

Mol. Cell. Biol. 2010
Participants
Input
Output
Participates
as an event of
Orthologous Events
POLN binds ICL-DNA (Bos taurus)
POLN binds ICL-DNA (Canis familiaris)
POLN binds ICL-DNA (Danio rerio)
POLN binds ICL-DNA (Mus musculus)
POLN binds ICL-DNA (Rattus norvegicus)
POLN binds ICL-DNA (Sus scrofa)
POLN binds ICL-DNA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-06-29)
Reviewed
Fugger, K  (2015-08-20)
Created
Orlic-Milacic, M  (2015-07-03)
Cite Us!