POLN binds ICL-DNA

Stable Identifier
R-HSA-6786155
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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POLN binds ICL-DNA
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An error-prone DNA polymerase nu (POLN) is recruited to the interstrand crosslink (ICL) repair site through interaction with monoubiquitinated FANCD2 and probably the PCNA subunit of the stalled replication complex (Moldovan et al. 2010).

Literature References
PubMed ID Title Journal Year
19995904 DNA polymerase POLN participates in cross-link repair and homologous recombination

Moldovan, GL, Madhavan, MV, Mirchandani, KD, McCaffrey, RM, Vinciguerra, P, D'Andrea, AD

Mol. Cell. Biol. 2010
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
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POLN binds ICL-DNA (Danio rerio)
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POLN binds ICL-DNA (Mus musculus)
POLN binds ICL-DNA (Rattus norvegicus)
POLN binds ICL-DNA (Sus scrofa)
POLN binds ICL-DNA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-06-29)
Reviewed
Fugger, K  (2015-08-20)
Created
Orlic-Milacic, M  (2015-07-03)