JAK1 binds IL4R in IL13-bound IL13R type II

Stable Identifier
R-HSA-6786110
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
JAK1 binds IL4R in IL13-bound IL13R type II
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In response to Interleukin-13 ( IL13) binding, Janus kinase 1 (JAK1) binds to Interleukin-4 receptor alpha subunit (IL4R) (Roy et al. 2002). IL4R has 2 JAK binding motifs so it is believed that IL4R can bind JAK2 constitutively and additionally bind JAK1 upon ligand binding. The molecular trigger for JAK1 binding is not clear.
Literature References
PubMed ID Title Journal Year
12223527 IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats

Roy, B, Ford, D, Maizel, AL, Cathcart, MK, Bhattacharjee, A, Xu, B

J. Leukoc. Biol. 2002
Participants
Input
Output
Participates
as an event of
Orthologous Events
JAK1 binds IL4R in IL13-bound IL13R type II (Bos taurus)
JAK1 binds IL4R in IL13-bound IL13R type II (Canis familiaris)
JAK1 binds IL4R in IL13-bound IL13R type II (Gallus gallus)
JAK1 binds IL4R in IL13-bound IL13R type II (Mus musculus)
JAK1 binds IL4R in IL13-bound IL13R type II (Rattus norvegicus)
JAK1 binds IL4R in IL13-bound IL13R type II (Sus scrofa)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-07-03)
Cite Us!