JAK1 phosphorylates STAT3,STAT6

Stable Identifier
R-HSA-6786095
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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JAK1 phosphorylates STAT3,STAT6
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Signal transducer and activator of transcription 3 (STAT3) and STAT6 are phosphorylated by Janus kinase 1 (JAK1) in response to Interleukin-4 (IL4) (Bhattacharjee et al. 2013). STAT3 is phosphorylated on Y705, STAT6 is phosphorylated on Y641, residues critical for their function (Schindler & Darnell 1995, Mikita et al. 1996).
Literature References
PubMed ID Title Journal Year
23124025 IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages

Yakubenko, VP, Mulya, A, Cathcart, MK, Kundu, S, Bhattacharjee, A, Shukla, M

Free Radic. Biol. Med. 2013
Participants
Input
Output
Participates
as an event of
Catalyst Activity

non-membrane spanning protein tyrosine kinase activity of IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane]

Physical Entity
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Homo sapiens)
Activity
non-membrane spanning protein tyrosine kinase activity (GO:0004715)
Orthologous Events
JAK1 phosphorylates STAT3,STAT6 (Bos taurus)
JAK1 phosphorylates STAT3,STAT6 (Canis familiaris)
JAK1 phosphorylates STAT3,STAT6 (Gallus gallus)
JAK1 phosphorylates STAT3,STAT6 (Mus musculus)
JAK1 phosphorylates STAT3,STAT6 (Rattus norvegicus)
JAK1 phosphorylates STAT3,STAT6 (Sus scrofa)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-07-03)
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