JAK1 phosphorylates STAT3,STAT6

Stable Identifier
R-HSA-6786095
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
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JAK1 phosphorylates STAT3,STAT6
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Signal transducer and activator of transcription 3 (STAT3) and STAT6 are phosphorylated by Janus kinase 1 (JAK1) in response to Interleukin-4 (IL4) (Bhattacharjee et al. 2013). STAT3 is phosphorylated on Y705, STAT6 is phosphorylated on Y641, residues critical for their function (Schindler & Darnell 1995, Mikita et al. 1996).

Literature References
PubMed ID Title Journal Year
23124025 IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages

Bhattacharjee, A, Shukla, M, Yakubenko, VP, Mulya, A, Kundu, S, Cathcart, MK

Free Radic. Biol. Med. 2013
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
non-membrane spanning protein tyrosine kinase activity of IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane]
Physical Entity
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane]
Activity
non-membrane spanning protein tyrosine kinase activity (0004715)
Orthologous Events
JAK1 phosphorylates STAT3,STAT6 (Bos taurus)
JAK1 phosphorylates STAT3,STAT6 (Canis familiaris)
JAK1 phosphorylates STAT3,STAT6 (Danio rerio)
JAK1 phosphorylates STAT3,STAT6 (Mus musculus)
JAK1 phosphorylates STAT3,STAT6 (Rattus norvegicus)
JAK1 phosphorylates STAT3,STAT6 (Xenopus tropicalis)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-07-03)