Signal transducer and activator of transcription 3 (STAT3) and STAT6 are phosphorylated by Janus kinase 1 (JAK1) in response to Interleukin-4 (IL4) (Bhattacharjee et al. 2013). STAT3 is phosphorylated on Y705, STAT6 is phosphorylated on Y641, residues critical for their function (Schindler & Darnell 1995, Mikita et al. 1996).
Yakubenko, VP, Mulya, A, Cathcart, MK, Kundu, S, Bhattacharjee, A, Shukla, M
non-membrane spanning protein tyrosine kinase activity of IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane]
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