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p-Y705-STAT3,p-Y641-STAT6 dissociate
Stable Identifier
R-HSA-6786072
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
p-Y705-STAT3,p-Y641-STAT6 dissociate (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once phosphorylated, Signal transducer and activator of transcription 3 (STAT3) and STAT6 dissociate from the IL4 receptor/JAK1 complex.
Literature References
PubMed ID
Title
Journal
Year
23124025
IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages
Yakubenko, VP
,
Mulya, A
,
Cathcart, MK
,
Kundu, S
,
Bhattacharjee, A
,
Shukla, M
Free Radic. Biol. Med.
2013
Participants
Input
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane]
(Homo sapiens)
Output
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane]
(Homo sapiens)
p-Y705-STAT3,p-Y641-STAT6 [cytosol]
(Homo sapiens)
Participates
as an event of
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Orthologous Events
p-Y705-STAT3,p-Y641-STAT6 dissociate (Bos taurus)
p-Y705-STAT3,p-Y641-STAT6 dissociate (Canis familiaris)
p-Y705-STAT3,p-Y641-STAT6 dissociate (Gallus gallus)
p-Y705-STAT3,p-Y641-STAT6 dissociate (Mus musculus)
p-Y705-STAT3,p-Y641-STAT6 dissociate (Rattus norvegicus)
p-Y705-STAT3,p-Y641-STAT6 dissociate (Sus scrofa)
Authored
Jupe, S (2015-07-01)
Reviewed
Leibovich, SJ (2016-09-02)
Created
Jupe, S (2015-07-03)
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