Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A complex composed of FANCM and FAAP24 is constitutively associated with chromatin (Ciccia et al. 2007, Kim et al. 2008). Chromatin localization of the FANCM:FAAP24 complex is facilitated by the octameric MHF complex (Tao et al. 2012) composed of four dimers of two histone-like proteins: APITD1 (MHF1, FAAP16) and STRA13 (MHF2, FAAP10) (Singh et al. 2010). The complex of FANCM, FAAP24, APITD1 and STRA13 may constitute a molecular machine that preferentially binds to replication forks stalled at DNA interstrand crosslinks (ICL-DNA), with FANCM preferentially binding to the branch point, FAAP24 to the single strand DNA (ssDNA) and the MHF complex to the double strand DNA (Yan et al. 2010).

Literature References
PubMed ID Title Journal Year
18174376 Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24

Gurtan, A, D'Andrea, AD, Kim, JM, Kee, Y

Blood 2008
20347429 MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM

Pierce, AJ, Singh, TR, Wahengbam, K, Ali, AM, Sachpatzidis, A, Zheng, XF, Meetei, AR, Du, CH, Sung, P, Killen, MW, Xiong, Y, Saro, D

Mol. Cell 2010
20347428 A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability

Shen, X, Joenje, H, Constantinou, A, Sen, R, Daee, D, Oostra, AB, D├ęcaillet, C, Stasiak, A, Stone, S, Hoatlin, ME, Wang, W, Steltenpool, J, Muniandy, PA, Osman, F, Myung, K, Whitby, MC, Schindler, D, Stasiak, AZ, Yan, Z, Lin, T, Seidman, MM, Li, L, Delannoy, M, Du, H, de Winter, JP, Ling, C, Schuster, B, Woodcock, CL

Mol. Cell 2010
17289582 Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM

West, SC, Xue, Y, de Winter, JP, Joenje, H, McDonald, N, Ling, C, Meetei, AR, Coulthard, R, Yan, Z, Laghmani, el H, Wang, W, Ciccia, A

Mol. Cell 2007
22510687 The structure of the FANCM-MHF complex reveals physical features for functional assembly

Chu, L, Jin, C, Niu, L, Qi, S, Li, X, Tao, Y, Teng, M, Yao, X

Nat Commun 2012
Cite Us!