Reactome | HSPG binds LPL dimer

HSPG binds LPL dimer

Stable Identifier

R-HSA-6784861

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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LPL enzyme is catalytically active as a dimer composed of two glycosylated subunits of LPL connected in a head-to-tail arrangement by non-covalent interactions. It is synthesised in adipocytes and exported to the luminal side of the capillary endothelium where it binds heparan sulfate proteoglycan (HSPG), serving as an membrane anchor for the LPL dimer (Lookene et al. 1997, Berryman & Bensadoun 1995).

Literature References

PubMed ID	Title	Journal	Year
9136889	Interaction of lipoproteins with heparan sulfate proteoglycans and with lipoprotein lipase. Studies by surface plasmon resonance technique Savonen, R, Lookene, A, Olivecrona, G	Biochemistry	1997
7592670	Heparan sulfate proteoglycans are primarily responsible for the maintenance of enzyme activity, binding, and degradation of lipoprotein lipase in Chinese hamster ovary cells Berryman, DE, Bensadoun, A	J. Biol. Chem.	1995