PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome

Stable Identifier
R-HSA-6784729
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endolysosome membrane, plasma membrane
ReviewStatus
5/5
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PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome
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The PCSK9:LDLR:Clathrin-coated vesicle is internalized to endosomes and, after that, to lysosomes where PCSK9 and LDLR are degraded (Wang et al. 2012).
Literature References
PubMed ID Title Journal Year
22764087 Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

Huang, Y, Hobbs, HH, Cohen, JC, Wang, Y

J. Lipid Res. 2012
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as an event of
Orthologous Events
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Bos taurus)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Caenorhabditis elegans)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Canis familiaris)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Dictyostelium discoideum)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Drosophila melanogaster)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Gallus gallus)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Mus musculus)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Rattus norvegicus)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Saccharomyces cerevisiae)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Schizosaccharomyces pombe)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Sus scrofa)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Xenopus tropicalis)
Authored
Sanchis, A  (2015-05-12)
Reviewed
D'Eustachio, P  (2016-04-20)
Created
Sanchis, A  (2015-06-22)
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