PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome

Stable Identifier
R-HSA-6784729
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The PCSK9:LDLR:Clathrin-coated vesicle is internalized to endosomes and, after that, to lysosomes where PCSK9 and LDLR are degraded (Wang et al. 2012).

Literature References
PubMed ID Title Journal Year
22764087 Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

Wang, Y, Huang, Y, Hobbs, HH, Cohen, JC

J. Lipid Res. 2012
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