Reactome | USP21 deubiquitinates GATA3,IL33

USP21 deubiquitinates GATA3,IL33

Stable Identifier

R-HSA-6783177

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Though not required for normal development (Pannu et al. 2015), USP21 is essential in innate and adaptive immune responses (Tao et al. 2014). It deubiquitinates the Th2 specific transcription factor GATA3. This positive regulation is important for the function of regulatory T cells (Zhang et al. 2013). USP21 also deubiquitinates IL-33, which is both a cytokine and a chromatin-associated nuclear protein known as Nuclear factor from high endothelial venule (NF-HEV), which is associated with many inflammatory diseases (Garlanda et al. 2013). IL-33 can bind to the RELA (NFkB p65) promoter region, inducing endothelial cell activation (Choi et al. 2012). Depletion of USP21 reduces IL-33 protein levels and IL-33-mediated RELA promoter activity (Tao et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
23395819	Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3 Yang, J, Gao, Z, Chen, C, Pan, L, Li, B, Shi, G, Wen, C, Tsun, A, Gao, Y, Zhang, J, Tao, L, Hou, X, Yao, Z, Lin, F	J. Biol. Chem.	2013
25197364	Deubiquitination and stabilization of IL-33 by USP21 Piccioni, M, Tao, L, Song, H, Chen, C, Li, B, Shi, G	Int J Clin Exp Pathol	2014