UV-DDB ubiquitinates XPC

Stable Identifier
Reaction [transition]
Homo sapiens
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The role of UV-DDB-mediated ubiquitination in global genome nucleotide excision repair (GG-NER) has not been fully elucidated.

In the absence of DNA damage, the ubiquitin ligase activity of UV-DDB complex is inhibited by association with the COP9 signalosome (CSN complex), which dissociates from the UV-DDB complex upon binding to damaged DNA (Groisman et al. 2003, Fischer et al. 2011). Ubiquitination of XPC by UV-DDB promotes XPC retention at GG-NER sites, while progressive autoubiquitination of UV-DDB promotes the dissociation of UV-DDB from the DNA and may act as an intracellular signal (Sugasawa et al. 2005). The UV-DDB complex also ubiquitinates histones H2A, H3 and H4, which may trigger chromatin remodeling at DNA damage site and regulate the accessibility of damaged DNA to repair factors (Kapetanaki et al. 2006, Wang et al. 2006).

Literature References
PubMed ID Title Journal Year
16473935 The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites

Kapetanaki, MG, Bisi, DC, Hsieh, CL, Guerrero-Santoro, J, Levine, AS, Rapić-Otrin, V

Proc. Natl. Acad. Sci. U.S.A. 2006
22118460 The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation

Lingaraju, GM, Gut, H, Yasuda, T, Iwai, S, Thomä, NH, Sugasawa, K, Scrima, A, Fischer, ES, Cavadini, S, Böhm, K, Hanaoka, F, Wakasugi, M, Faty, M, Matsumoto, S

Cell 2011
15882621 UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex

Okuda, Y, Mori, T, Tanaka, K, Saijo, M, Tanaka, K, Iwai, S, Matsuda, N, Sugasawa, K, Hanaoka, F, Nishi, R, Chu, G

Cell 2005
16678110 Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage

Xiong, Y, Zhai, L, Zhang, Y, Wang, H, Tempst, P, Jackson, S, Joo, HY, Erdjument-Bromage, H, Xu, J

Mol. Cell 2006
Catalyst Activity

ubiquitin protein ligase activity of XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm]

Orthologous Events
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