USP17 deubiquitinates SUDS3

Stable Identifier
R-HSA-6782820
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
USP17 deubiquitinates SUDS3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
USP17 removes Lys-63-linked ubiquitin chains from SDS3, a key component of the histone deacetylase (HDAC)-dependent Sin3A co-repressor complex, serving to maintain its HDAC activity (Ramakrishna et al. 2011).
Literature References
PubMed ID Title Journal Year
21239494 Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity

Ahn, WS, Suresh, B, Lee, EJ, Ramakrishna, S, Baek, KH, Lee, HJ

J. Biol. Chem. 2011
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type deubiquitinase activity of USP17:K63polyUb-SUDS3 [nucleoplasm]

Physical Entity
USP17:K63polyUb-SUDS3 [nucleoplasm] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
USP17 deubiquitinates SUDS3 (Bos taurus)
USP17 deubiquitinates SUDS3 (Canis familiaris)
USP17 deubiquitinates SUDS3 (Danio rerio)
USP17 deubiquitinates SUDS3 (Dictyostelium discoideum)
USP17 deubiquitinates SUDS3 (Drosophila melanogaster)
USP17 deubiquitinates SUDS3 (Mus musculus)
USP17 deubiquitinates SUDS3 (Rattus norvegicus)
USP17 deubiquitinates SUDS3 (Saccharomyces cerevisiae)
USP17 deubiquitinates SUDS3 (Schizosaccharomyces pombe)
USP17 deubiquitinates SUDS3 (Sus scrofa)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-09)
Cite Us!