USP17 deubiquitinates SUDS3

Stable Identifier
R-HSA-6782820
Type
Reaction
Species
Homo sapiens
Compartment
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USP17 removes Lys-63-linked ubiquitin chains from SDS3, a key component of the histone deacetylase (HDAC)-dependent Sin3A co-repressor complex, serving to maintain its HDAC activity (Ramakrishna et al. 2011).

Literature References
PubMed ID Title Journal Year
21239494 Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity

Ramakrishna, S, Suresh, B, Lee, EJ, Lee, HJ, Ahn, WS, Baek, KH

J. Biol. Chem. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP17:K63polyUb-SUDS3 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created