USP17 deubiquitinates SUDS3

Stable Identifier
R-HSA-6782820
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP17 removes Lys-63-linked ubiquitin chains from SDS3, a key component of the histone deacetylase (HDAC)-dependent Sin3A co-repressor complex, serving to maintain its HDAC activity (Ramakrishna et al. 2011).

Literature References
PubMed ID Title Journal Year
21239494 Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity

Ramakrishna, S, Suresh, B, Lee, EJ, Lee, HJ, Ahn, WS, Baek, KH

J. Biol. Chem. 2011
Participants
Participates
Catalyst Activity

thiol-dependent ubiquitin-specific protease activity of USP17:K63polyUb-SUDS3 [nucleoplasm]

Orthologous Events
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