QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr)

Stable Identifier
R-HSA-6782443
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The transglycosylase complex QTRT1:QTRTD1 exchanges guanine for queuine at nucleotide 34 of tRNA(Tyr) (Chen et al. 2010, Chen et al. 2011). The QTRT1 subunit is responsible for the transglycosylase activity. Eukaryotes are unable to synthesize queuine and must obtain it from dietary sources or symbiotic gut flora. As inferred from the mouse homologs, QTRT1:QTRTD1 associates with the outer mitochondrial membrane (Boland et al. 2009). The homologous enzyme in Escherichia coli is tgt.

Literature References
PubMed ID Title Journal Year
20354154 Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure

Chen, YC, Kelly, VP, Stachura, SV, Garcia, GA

RNA 2010
21131277 Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases

Chen, YC, Brooks, AF, Goodenough-Lashua, DM, Kittendorf, JD, Showalter, HD, Garcia, GA

Nucleic Acids Res. 2011
19414587 Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase

Boland, C, Hayes, P, Santa-Maria, I, Nishimura, S, Kelly, VP

J. Biol. Chem. 2009
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
queuine tRNA-ribosyltransferase activity of QTRT1:QTRTD1 [mitochondrial outer membrane]
Physical Entity
Activity
Authored
Reviewed
Created
Cite Us!