ADAT1 deaminates adenosine-37 of tRNA(Ala) yielding inosine-37, which may then be methylated to N1-methylinosine-37 (Maas et al. 1999). The homologue in Saccharomyces, Tad1p, catalyzes the same reaction, indicating the deamination of adenosine-37 is highly conserved in eukaryotes.
Gerber, AP, Maas, S, Rich, A
tRNA-specific adenosine deaminase activity of ADAT1 [nucleoplasm]
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