ADAT1 deaminates adenosine-37 in tRNA(Ala)

Stable Identifier
R-HSA-6782336
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ADAT1 deaminates adenosine-37 of tRNA(Ala) yielding inosine-37, which may then be methylated to N1-methylinosine-37 (Maas et al. 1999). The homologue in Saccharomyces, Tad1p, catalyzes the same reaction, indicating the deamination of adenosine-37 is highly conserved in eukaryotes.

Literature References
PubMed ID Title Journal Year
10430867 Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes

Maas, S, Gerber, AP, Rich, A

Proc. Natl. Acad. Sci. U.S.A. 1999
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Catalyst Activity

tRNA-specific adenosine deaminase activity of ADAT1 [nucleoplasm]

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