Reactome | YOD1 binds VCP

YOD1 binds VCP

Stable Identifier

R-HSA-6781953

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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YOD1 (OTU1) is a highly conserved deubiquitinating enzyme of the ovarian tumor (otubain) family. It forms a complex with Valosin containing protein (VCP, p97) that may participate in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins (Ernst et al. 2009, Kim et al. 2014). It may act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel.

Literature References

PubMed ID	Title	Journal	Year
24610782	Structural basis for ovarian tumor domain-containing protein 1 (OTU1) binding to p97/valosin-containing protein (VCP) Kim, SJ, Cho, J, Song, EJ, Kim, SJ, Kim, HM, Lee, KE, Suh, SW, Kim, EE	J. Biol. Chem.	2014
19818707	The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER Ernst, R, Mueller, B, Ploegh, HL, Schlieker, C	Mol. Cell	2009