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USP13 binds SIAH2
Stable Identifier
R-HSA-6781899
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP13 binds SIAH2 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
USP13 mediates stabilization of the E3-ligase SIAH2 independently of deubiquitinase activity by binding and impairing SIAH2 autoubiquitination (Scortegagna et al. 2011).
Literature References
PubMed ID
Title
Journal
Year
21659512
USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains
Scortegagna, M
,
Gu, W
,
Kim, H
,
Kluger, H
,
Subtil, T
,
Qi, J
,
Ronai, ZA
,
Zhao, W
J. Biol. Chem.
2011
Participants
Input
SIAH2 [cytosol]
(Homo sapiens)
USP13 [cytosol]
(Homo sapiens)
Output
SIAH2:USP13 [cytosol]
(Homo sapiens)
Participates
as an event of
Ub-specific processing proteases (Homo sapiens)
Orthologous Events
USP13 binds SIAH2 (Bos taurus)
USP13 binds SIAH2 (Canis familiaris)
USP13 binds SIAH2 (Danio rerio)
USP13 binds SIAH2 (Drosophila melanogaster)
USP13 binds SIAH2 (Gallus gallus)
USP13 binds SIAH2 (Mus musculus)
USP13 binds SIAH2 (Rattus norvegicus)
USP13 binds SIAH2 (Sus scrofa)
Authored
Jupe, S (2015-04-16)
Reviewed
Meldal, BH (2016-05-16)
Created
Jupe, S (2015-06-03)
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