Cockayne syndrome protein A (ERCC8, also known as CSA) is recruited to a stalled RNA polymerase II complex (RNA Pol II) at a site of DNA damage in an ERCC6 (CSB) dependent manner (Fousteri et al. 2006). ERCC8 is part of an ubiquitin ligase complex that, in addition to ERCC8, also contains DDB1, CUL4 (CUL4A or CUL4B) and RBX1 (Groisman et al. 2003). The COP9 signalosome complex prevents the ubiquitin ligase activity of the ERCC8:DDB1:CUL4:RBX1 at the early steps after DNA damage induction (Groisman et al. 2003, Fischer et al. 2011).
Lingaraju, GM, Gut, H, Yasuda, T, Iwai, S, Thomä, NH, Sugasawa, K, Scrima, A, Fischer, ES, Cavadini, S, Böhm, K, Hanaoka, F, Wakasugi, M, Faty, M, Matsumoto, S
Fousteri, M, Mullenders, LH, van Zeeland, AA, Vermeulen, W
Drapkin, R, Kuraoka, I, Polanowska, J, Kisselev, AF, Tanaka, K, Saijo, M, Sawada, J, Groisman, R, Nakatani, Y
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