Reactome | GTF2A2 [nucleoplasm]

GTF2A2 [nucleoplasm]

Stable Identifier

R-HSA-65533

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription initiation factor IIA gamma chain, TFIIA P12 subunit, TFIIA-12, TFIIAS, TFIIA-gamma

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Nuclear Receptors (Homo sapiens)
  - ESR-mediated signaling (Homo sapiens)
    - Estrogen-dependent gene expression (Homo sapiens)
      - CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A2 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A2 [nucleoplasm] (Homo sapiens)
      - Estrogen-responsive TFF1 gene expression (Homo sapiens)
        
        ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1 [nucleoplasm] (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A2 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A2 [nucleoplasm] (Homo sapiens)
      - Histone acetyltransferases are recruited to the TFF1 gene (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1 [nucleoplasm] (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A2 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A2 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1 [nucleoplasm] (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A2 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A2 [nucleoplasm] (Homo sapiens)
      - PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A2 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A2 [nucleoplasm] (Homo sapiens)
      - TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A2 [nucleoplasm] (Homo sapiens)
        
        TFIIA [nucleoplasm] (Homo sapiens)
        
        GTF2A2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P52657 GTF2A2

Gene Names

GTF2A2, TF2A2

Chain

chain:1-109

Reference Genes

BioGPS Gene:2958 GTF2A2

COSMIC (genes):GTF2A2 GTF2A2

CTD Gene:2958 GTF2A2

dbSNP Gene:2958 GTF2A2

ENSEMBL:ENSG00000140307 GTF2A2

HGNC:4647 GTF2A2

KEGG Gene (Homo sapiens):2958 GTF2A2

Monarch:2958 GTF2A2

NCBI Gene:2958 GTF2A2

OMIM:600519 GTF2A2

UCSC:P52657 GTF2A2

Reference Transcript

Other Identifiers

0003710717

11723034_at

11723035_s_at

11754097_x_at

11757381_x_at

16810025

202678_PM_at

202678_at

230376_PM_at

230376_at

2958

3627043

3627044

3627045

3627046

3627048

3627053

3627056

3627057

3627061

3627064

3627065

3627070

37010_at

64672_at

7989315

869_at

A_24_P270525

A_33_P3415957

GE58949

GO:0001091

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005669

GO:0005672

GO:0006366

GO:0006367

GO:0008134

GO:0008150

GO:0009058

GO:0016251

GO:0017025

GO:0022607

GO:0030054

GO:0032991

GO:0034641

GO:0042803

GO:0043226

GO:0045944

GO:0046982

GO:0051123

GO:0060261

GO:0065003

HMNXSV003007315

Hs.44324.0.A1_3p_at

ILMN_1753719

PH_hs_0023416

TC15001501.hg

U14193_at

g4758485_3p_s_at

Participates

as a component of

TFIIA [nucleoplasm] (Homo sapiens)

Inferred To

TfIIA-S [nucleoplasm] (Drosophila melanogaster)

Gtf2a2 [nucleoplasm] (Mus musculus)

Gtf2a2 [nucleoplasm] (Rattus norvegicus)

GTF2A2 [nucleoplasm] (Bos taurus)

GTF2A2 [nucleoplasm] (Canis familiaris)

GTF2A2 [nucleoplasm] (Gallus gallus)

GTF2A2 [nucleoplasm] (Sus scrofa)

toa2 [nucleoplasm] (Schizosaccharomyces pombe)

gtf2a2 [nucleoplasm] (Danio rerio)

gtf2a2 [nucleoplasm] (Dictyostelium discoideum)

gtf2a2 [nucleoplasm] (Xenopus tropicalis)

TOA2 [nucleoplasm] (Saccharomyces cerevisiae)

gtf-2A2 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001307859.1, NP_001307858.1, NP_004483.1

OpenTargets

ENSG00000140307

HPA

ENSG00000140307-GTF2A2

GeneCards

P52657

Ensembl

ENST00000396061, ENSP00000379373, ENSP00000379375, ENSP00000379372, ENST00000396063, ENST00000396060, ENSG00000140307

PRO

P52657

Pharos - Targets

P52657

PDB

7NVT, 7EGB, 7ENA, 7NVS, 7EGA, 5FUR, 5IYA, 7EG9, 5IY9, 7NVR, 5IY7, 7EDX, 7EG7, 7LBM, 6MZM, 6O9L, 5IY8, 7EGJ, 7EG8, 5M4S, 5IY6, 7EGI, 1NVP, 7NVZ, 7ENC, 5IYD, 7NW0, 7NVY, 7EGD, 7NVU, 5IYB, 7EGC, 5IYC

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20226 TBP	1	TBP [nucleoplasm] (R-HSA-83718)	0.623	2

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