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PLCB4 [cytosol]
Stable Identifier
R-HSA-61697
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PLC beta 4, Phosphoinositide phospholipase C, PLC-beta-4, Phospholipase C-beta-4, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)
PLCbz [cytosol] (Homo sapiens)
PLCB4:Ca2+ [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Activation of PLC beta-1/4 (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
Inactivation of PLC beta (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PIP2 hydrolysis (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
PLC beta is activated by G alpha (q) (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15147 PLCB4
Gene Names
PLCB4
Chain
initiator methionine:1, chain:2-1175
Reference Genes
BioGPS Gene:5332 PLCB4
COSMIC (genes):PLCB4 PLCB4
CTD Gene:5332 PLCB4
dbSNP Gene:5332 PLCB4
ENSEMBL:ENSG00000101333 PLCB4
HGNC:9059 PLCB4
KEGG:hsa:5332 PLCB4
Monarch:5332 PLCB4
NCBI Gene:5332 PLCB4
OMIM:600810 PLCB4
UCSC:Q15147 PLCB4
Reference Transcript
RefSeq:NM_000933.3 PLCB4
RefSeq:NM_001377135.1 PLCB4
RefSeq:XM_017027880.1 PLCB4
RefSeq:NM_001172646.2 PLCB4
RefSeq:NM_182797.3 PLCB4
RefSeq:NM_001377134.2 PLCB4
RefSeq:XM_017027881.1 PLCB4
RefSeq:XM_047440202.1 PLCB4
RefSeq:NM_001377136.1 PLCB4
Other Identifiers
11738021_a_at
11743366_a_at
11743367_a_at
11755050_s_at
11756635_a_at
16911338
203895_PM_at
203895_at
203896_PM_s_at
203896_s_at
240728_PM_at
240728_at
35654_at
3875904
3875909
3875910
3875915
3875919
3875922
3875932
3875933
3875943
3875944
3875945
3875956
3875959
3875960
3875961
3875962
3875963
3875964
3875965
3875969
3875970
3875972
3875973
3875974
3875975
3875978
3875979
3875982
3875985
3875988
3875989
3875990
3875991
3875992
3875993
3875994
3875996
3875997
3875998
3875999
3876006
3876007
3876008
3876012
3876013
3876014
3876015
3876016
3876017
3876018
3876019
3876021
3876023
3876024
3876027
3876028
3876029
3876030
3876031
3876032
3876036
3876037
3876038
3876039
3876040
3876041
3876042
3876062
3876068
3876070
3876071
3876072
3876073
3876075
3876077
3876078
51335_at
5332
57899_r_at
8060897
80794_at
900_at
901_g_at
A_14_P122232
A_23_P28898
A_24_P509189
A_33_P3260634
A_33_P3353502
GE56091
GE80968
GO:0004435
GO:0004629
GO:0005509
GO:0005515
GO:0005634
GO:0005783
GO:0005790
GO:0005829
GO:0005886
GO:0006629
GO:0007165
GO:0007186
GO:0008081
GO:0012505
GO:0014069
GO:0016020
GO:0016042
GO:0016787
GO:0030425
GO:0035556
GO:0043226
GO:0046488
GO:0046872
GO:0048015
GO:0050804
GO:0051209
GO:0055085
GO:0098688
GO:0098794
GO:0098978
GO:0120548
GO:0160135
HMNXSV003012117
Hs.151408.0.A1_3p_at
Hs.283006.0.S2_3p_at
ILMN_1736426
ILMN_1851565
ILMN_2397294
L41349_at
PH_hs_0022684
RNA95535|RNS_617_146
TC20000076.hg
g4505866_3p_a_at
Participates
as a member of
PLC-beta [cytosol] (Homo sapiens)
as a component of
PLCB4:Ca2+ [cytosol] (Homo sapiens)
Inferred To
PLCB4 [cytosol]
(Bos taurus)
PLCB4 [cytosol]
(Canis familiaris)
PLCB4 [cytosol]
(Gallus gallus)
PLCB4 [cytosol]
(Plasmodium falciparum)
PLCB4 [cytosol]
(Sus scrofa)
plc [cytosol]
(Dictyostelium discoideum)
PLC1 [cytosol]
(Saccharomyces cerevisiae)
plc1 [cytosol]
(Schizosaccharomyces pombe)
norpA [cytosol]
(Drosophila melanogaster)
Plcb4 [cytosol]
(Mus musculus)
Plcb4 [cytosol]
(Rattus norvegicus)
plcb4 [cytosol]
(Xenopus tropicalis)
egl-8 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001364065.1
,
XP_047296158.1
,
XP_016883370.1
,
XP_016883369.1
,
NP_877949.2
,
NP_001364063.1
,
NP_001166117.1
,
NP_001364064.1
,
NP_000924.3
Guide to Pharmacology - Targets
1406
OpenTargets
ENSG00000101333
ENSEMBL
ENSP00000367754
,
ENSP00000510118
,
ENSP00000510632
,
ENSG00000101333
,
ENST00000378501
,
ENST00000693752
,
ENSP00000508595
,
ENSP00000508676
,
ENSP00000508677
,
ENSP00000508650
,
ENST00000686976
,
ENST00000685823
,
ENST00000686313
,
ENST00000686871
,
ENST00000688656
,
ENSP00000510302
,
ENSP00000367762
,
ENSP00000510124
,
ENST00000693005
,
ENSP00000509597
,
ENSP00000508600
,
ENST00000685310
,
ENSP00000509912
,
ENST00000378493
,
ENST00000689910
,
ENST00000685110
,
ENST00000685859
HPA
ENSG00000101333-PLCB4
GeneCards
PLCB4
PRO
Q15147
Pharos - Targets
Q15147
Orphanet
PLCB4
GlyGen
Q15147
HMDB Protein
HMDBP00223
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