F2RL2(22-374)

Stable Identifier
R-HSA-61313
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Proteinase activated receptor 3, PAR-3, Thrombin receptor- like 2, Coagulation factor II receptor-like 2
Locations in the PathwayBrowser
Summation

This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.

External Reference Information
External Reference
Gene Names
F2RL2, PAR3
Chain
signal peptide:1-21, propeptide:22-38, chain:39-374
Other Identifiers
0001850398
11726743_at
11750321_a_at
16997383
206795_at
2151
230147_at
2863365
2863366
2863367
2863368
2863369
2863370
2863373
2863374
31972_at
45204_s_at
62120_at
8112731
A_23_P144718
A_32_P60065
AAC51218
AAH93648
AAH93650
AAK51564
AC026725
AF374726
AK298585
AK312848
BAG35701
BAG60775
BC093648
BC093650
BX537386
CAD97628
CCDS4031
CCDS58959
CH471084
EAW95778
ENSG00000164220
ENSP00000296641
ENSP00000426703
ENST00000296641
ENST00000504899
EntrezGene:2151
F2RL2
F2RL2-201
F2RL2-202
g4758325_3p_at
g4758325_3p_x_at
GE79179
GO:0003674
GO:0004435
GO:0004871
GO:0004930
GO:0005515
GO:0005575
GO:0005576
GO:0005623
GO:0005886
GO:0005887
GO:0006950
GO:0007165
GO:0007186
GO:0007596
GO:0007599
GO:0008150
GO:0009611
GO:0015057
GO:0016020
GO:0016021
GO:0016324
GO:0030168
GO:0032991
GO:0035025
GO:0042592
GO:0051482
GO:0070493
HGNC:3539
Hs.42502.0.A1_3p_at
ILMN_1728923
ILMN_2202894
IPR000276
IPR003912
IPR003943
IPR017452
MIM:601919
NM_001256566
NM_004101
NP_001243495
NP_004092
PF00001
PH_hs_0003115
PR00237
PR01428
PR01429
TC05001502.hg
U92971
U92971_at
uc003kem.4
uc011csw.3
UPI0000050431
UPI00017A7898
Participant Of
Other forms of this molecule
Inferred To
Cross References
GeneCards
PRO
Interactors (1)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q8NI35 PATJ  1 0.463 2