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F2RL2(22-374) [plasma membrane]
Stable Identifier
R-HSA-61313
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Proteinase activated receptor 3, PAR-3, Thrombin receptor- like 2, Coagulation factor II receptor-like 2
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Homo sapiens)
PAR3, 4 [plasma membrane] (Homo sapiens)
F2RL2(22-374) [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
Proteinase-activated receptors [plasma membrane] (Homo sapiens)
F2RL2(22-374) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
Proteinase-activated receptors [plasma membrane] (Homo sapiens)
F2RL2(22-374) [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
Proteinase-activated receptors [plasma membrane] (Homo sapiens)
F2RL2(22-374) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
Proteinase-activated receptors [plasma membrane] (Homo sapiens)
F2RL2(22-374) [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
Proteinase-activated receptors [plasma membrane] (Homo sapiens)
F2RL2(22-374) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
Proteinase-activated receptors [plasma membrane] (Homo sapiens)
F2RL2(22-374) [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Proteinase-activated receptors can bind thrombin (Homo sapiens)
Proteinase-activated receptors [plasma membrane] (Homo sapiens)
F2RL2(22-374) [plasma membrane] (Homo sapiens)
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
Proteinase-activated receptors [plasma membrane] (Homo sapiens)
F2RL2(22-374) [plasma membrane] (Homo sapiens)
General
This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.
External Reference Information
External Reference
UniProt:O00254 F2RL2
Gene Names
F2RL2, PAR3
Chain
signal peptide:1-21, propeptide:22-38, chain:39-374
Reference Genes
BioGPS Gene:2151 F2RL2
COSMIC (genes):F2RL2 F2RL2
CTD Gene:2151 F2RL2
dbSNP Gene:2151 F2RL2
ENSEMBL:ENSG00000164220 F2RL2
HGNC:3539 F2RL2
KEGG:hsa:2151 F2RL2
Monarch:2151 F2RL2
NCBI Gene:2151 F2RL2
OMIM:601919 F2RL2
UCSC:O00254 F2RL2
Reference Transcript
RefSeq:NM_004101.3 F2RL2
RefSeq:NM_001256566.1 F2RL2
Other Identifiers
11726743_at
11750321_a_at
16997383
206795_PM_at
206795_at
2151
230147_PM_at
230147_at
2863362
2863364
2863365
2863366
2863367
2863368
2863369
2863370
2863373
2863374
31972_at
45204_s_at
62120_at
8112731
A_23_P144718
A_32_P60065
GE79179
GO:0001648
GO:0003824
GO:0004435
GO:0004930
GO:0005515
GO:0005576
GO:0005886
GO:0007186
GO:0007200
GO:0007596
GO:0009611
GO:0015057
GO:0016020
GO:0016324
GO:0016787
GO:0030168
GO:0032024
GO:0032991
GO:0035025
GO:0048018
GO:0060089
GO:0070493
GO:0098772
GO:1990806
HMNXSV003012197
Hs.42502.0.A1_3p_at
ILMN_1728923
ILMN_2202894
PH_hs_0003115
TC05001502.hg
U92971_at
g4758325_3p_at
g4758325_3p_x_at
Participates
as a member of
Proteinase-activated receptors [plasma membrane] (Homo sapiens)
PAR3, 4 [plasma membrane] (Homo sapiens)
Other forms of this molecule
F2RL2(22-38) [extracellular region]
F2RL2 [plasma membrane]
Inferred To
tm4sf21b [plasma membrane]
(Danio rerio)
f2rl2 [plasma membrane]
(Xenopus tropicalis)
F2rl2 [plasma membrane]
(Mus musculus)
F2rl2 [plasma membrane]
(Rattus norvegicus)
F2RL2 [plasma membrane]
(Bos taurus)
F2RL2 [plasma membrane]
(Canis familiaris)
F2RL2 [plasma membrane]
(Gallus gallus)
F2RL2 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001243495.1
,
NP_004092.1
Guide to Pharmacology - Targets
349
ENSEMBL
ENSP00000426703
,
ENSP00000296641
,
ENST00000296641
,
ENSG00000164220
,
ENST00000504899
OpenTargets
ENSG00000164220
GeneCards
F2RL2
HPA
ENSG00000164220-F2RL2
PRO
O00254
Pharos - Targets
O00254
GlyGen
O00254
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NI35 PATJ
1
PATJ [plasma membrane]
(R-HSA-420011)
0.463
2
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