F2RL2(22-374) [plasma membrane]

Stable Identifier
R-HSA-61313
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Proteinase activated receptor 3, PAR-3, Thrombin receptor- like 2, Coagulation factor II receptor-like 2
Icon
F2RL2(22-374) [plasma membrane] icon
F2RL2(22-374) [plasma membrane] icon
Locations in the PathwayBrowser
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General
This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.
External Reference Information
External Reference
UniProt:O00254 F2RL2
Gene Names
F2RL2, PAR3
Chain
signal peptide:1-21, propeptide:22-38, chain:39-374
Reference Genes
BioGPS Gene:2151 F2RL2
COSMIC (genes):F2RL2 F2RL2
CTD Gene:2151 F2RL2
dbSNP Gene:2151 F2RL2
ENSEMBL:ENSG00000164220 F2RL2
HGNC:3539 F2RL2
KEGG:hsa:2151 F2RL2
Monarch:2151 F2RL2
NCBI Gene:2151 F2RL2
OMIM:601919 F2RL2
UCSC:O00254 F2RL2
Reference Transcript
Other Identifiers
11726743_at
11750321_a_at
16997383
206795_PM_at
206795_at
2151
230147_PM_at
230147_at
2863362
2863364
2863365
2863366
2863367
2863368
2863369
2863370
2863373
2863374
31972_at
45204_s_at
62120_at
8112731
A_23_P144718
A_32_P60065
GE79179
GO:0001648
GO:0003824
GO:0004435
GO:0004930
GO:0005515
GO:0005576
GO:0005886
GO:0007186
GO:0007200
GO:0007596
GO:0009611
GO:0015057
GO:0016020
GO:0016324
GO:0016787
GO:0030168
GO:0032024
GO:0032991
GO:0035025
GO:0048018
GO:0060089
GO:0070493
GO:0098772
GO:1990806
HMNXSV003012197
Hs.42502.0.A1_3p_at
ILMN_1728923
ILMN_2202894
PH_hs_0003115
TC05001502.hg
U92971_at
g4758325_3p_at
g4758325_3p_x_at
Participates
as a member of
Other forms of this molecule
F2RL2(22-38) [extracellular region]
F2RL2 [plasma membrane]
Inferred To
tm4sf21b [plasma membrane] (Danio rerio)
f2rl2 [plasma membrane] (Xenopus tropicalis)
F2rl2 [plasma membrane] (Mus musculus)
F2rl2 [plasma membrane] (Rattus norvegicus)
F2RL2 [plasma membrane] (Bos taurus)
F2RL2 [plasma membrane] (Canis familiaris)
F2RL2 [plasma membrane] (Gallus gallus)
F2RL2 [plasma membrane] (Sus scrofa)
Cross References
RefSeq
Guide to Pharmacology - Targets
349
ENSEMBL
OpenTargets
GeneCards
HPA
PRO
Pharos - Targets
GlyGen
Interactors (1)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q8NI35 PATJ  1 0.463 2
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