Reactome | Netrin-4 binds DCC/UNC5A

Netrin-4 binds DCC/UNC5A

Stable Identifier

R-HSA-593685

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

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DCC and UNC5A, are also receptors for Netrin-4. The LNT domain of Netrin-4 is the key domain for this specific binding. Netrin-4 might also mediate attractive action through DCC and repulsive action through UNC5A.

Literature References

PubMed ID	Title	Journal	Year
17174565	Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains Qin, S, Yu, L, Gao, Y, Zhou, R, Zhang, C	Mol Cell Neurosci	2007