Netrin-4 binds DCC/UNC5A

Stable Identifier
R-HSA-593685
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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Netrin-4 binds DCC/UNC5A
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DCC and UNC5A, are also receptors for Netrin-4. The LNT domain of Netrin-4 is the key domain for this specific binding. Netrin-4 might also mediate attractive action through DCC and repulsive action through UNC5A.

Literature References
PubMed ID Title Journal Year
17174565 Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains

Qin, S, Yu, L, Gao, Y, Zhou, R, Zhang, C

Mol Cell Neurosci 2007
Participants
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Participant Of
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Orthologous Events
Netrin-4 binds DCC/UNC5A (Bos taurus)
Netrin-4 binds DCC/UNC5A (Caenorhabditis elegans)
Netrin-4 binds DCC/UNC5A (Canis familiaris)
Netrin-4 binds DCC/UNC5A (Danio rerio)
Netrin-4 binds DCC/UNC5A (Drosophila melanogaster)
Netrin-4 binds DCC/UNC5A (Gallus gallus)
Netrin-4 binds DCC/UNC5A (Mus musculus)
Netrin-4 binds DCC/UNC5A (Rattus norvegicus)
Netrin-4 binds DCC/UNC5A (Sus scrofa)
Netrin-4 binds DCC/UNC5A (Xenopus tropicalis)
Authored
Garapati, P V  (2010-04-13)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2010-04-13)