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PRPS2 [cytosol]
Stable Identifier
R-HSA-58224
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
phosphoribosyl pyrophosphate synthetase 2, Ribose-phosphate pyrophosphokinase II (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase II) (PPRibP) (PRS-II), Ribose-phosphate pyrophosphokinase II , Phosphoribosyl pyrophosphate synthetase II, PPRibP, PRS-II
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Pentose phosphate pathway (Homo sapiens)
5-Phosphoribose 1-diphosphate biosynthesis (Homo sapiens)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Homo sapiens)
PRPS2 dimer, PRPS1L dimer [cytosol] (Homo sapiens)
phosphoriboyl pyrophosphate synthetase 2 putative holoenzyme [cytosol] (Homo sapiens)
PRPS2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11908 PRPS2
Gene Names
PRPS2
Chain
initiator methionine:, chain:2-318
Reference Genes
BioGPS Gene:5634 PRPS2
COSMIC (genes):PRPS2 PRPS2
CTD Gene:5634 PRPS2
dbSNP Gene:5634 PRPS2
ENSEMBL:ENSG00000101911 PRPS2
HGNC:9465 PRPS2
KEGG:hsa:5634 PRPS2
Monarch:5634 PRPS2
NCBI Gene:5634 PRPS2
OMIM:311860 PRPS2
UCSC:P11908 PRPS2
Reference Transcript
RefSeq:NM_001039091.2 PRPS2
RefSeq:NM_002765.4 PRPS2
Other Identifiers
11718134_a_at
11718135_at
17101517
203401_PM_at
203401_at
3969048
3969049
3969057
3969058
3969061
3969063
3969064
3969065
3969066
3969073
3969074
3969076
3969077
3969078
3969080
41490_at
5634
8166049
A_23_P96641
A_24_P117528
A_33_P3411122
GE60237
GO:0000287
GO:0002189
GO:0003824
GO:0004749
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0006015
GO:0006091
GO:0006098
GO:0006139
GO:0006164
GO:0009156
GO:0009165
GO:0016301
GO:0016740
GO:0042802
GO:0042803
GO:0044249
GO:0046872
GO:0055086
GO:1901135
HMNXSV003047330
ILMN_1758104
ILMN_2399431
PH_hs_0022256
TC0X000050.hg
Y00971_at
g4506128_3p_at
Participates
as a component of
phosphoriboyl pyrophosphate synthetase 2 putative holoenzyme [cytosol] (Homo sapiens)
Inferred To
PRPS1L1 [cytosol]
(Dictyostelium discoideum)
PRPS1L1 [cytosol]
(Plasmodium falciparum)
PRPS1L1 [cytosol]
(Saccharomyces cerevisiae)
PRPS1L1 [cytosol]
(Schizosaccharomyces pombe)
Homologues of PRPS1L1 [cytosol]
(Dictyostelium discoideum)
Homologues of PRPS1L1 [cytosol]
(Plasmodium falciparum)
Homologues of PRPS1L1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of PRPS1L1 [cytosol]
(Schizosaccharomyces pombe)
PRPS2 [cytosol]
(Bos taurus)
PRPS2 [cytosol]
(Canis familiaris)
PRPS2 [cytosol]
(Gallus gallus)
PRPS2 [cytosol]
(Mus musculus)
PRPS2 [cytosol]
(Rattus norvegicus)
PRPS2 [cytosol]
(Sus scrofa)
PRPS2 [cytosol]
(Xenopus tropicalis)
PRPS1 [cytosol]
(Dictyostelium discoideum)
PRPS1 [cytosol]
(Plasmodium falciparum)
PRPS1 [cytosol]
(Saccharomyces cerevisiae)
PRPS1 [cytosol]
(Schizosaccharomyces pombe)
Cross References
ENSEMBL
ENST00000398491
,
ENST00000380668
,
ENSP00000381504
,
ENSP00000370043
OpenTargets
ENSG00000101911
HPA
ENSG00000101911-PRPS2
PRO
P11908
Pharos - Targets
P11908
GlyGen
P11908
HMDB Protein
HMDBP00632
PDB
7YK1
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:Q9Y3M2 CBY1
3
CBY1 [nucleoplasm]
(R-HSA-3769210)
pS20-CBY1 [nucleoplasm]
(R-HSA-3769356)
pS20-CBY1 [cytosol]
(R-HSA-3769354)
0.508
2
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