Reactome | PRKCH [cytosol]

PRKCH [cytosol]

Stable Identifier

R-HSA-58208

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein kinase C, eta type , nPKC-eta, PKC-L

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Effects of PIP2 hydrolysis (Homo sapiens)
        
        Activation of Protein Kinase C novel isoforms (Homo sapiens)
        
        Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
        
        PRKCH [cytosol] (Homo sapiens)
        
        Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
        
        PRKCH [cytosol] (Homo sapiens)
    - G alpha (z) signalling events (Homo sapiens)
      - G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
        
        PRKCH [cytosol] (Homo sapiens)
        
        p(S27)-G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
        
        PRKCH [cytosol] (Homo sapiens)
      - PKC binds active G alpha (z) (Homo sapiens)
        
        G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
        
        PRKCH [cytosol] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
        
        PRKCH [cytosol] (Homo sapiens)
      - PKC phosphorylates G alpha (z) (Homo sapiens)
        
        G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
        
        PRKCH [cytosol] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
        
        PRKCH [cytosol] (Homo sapiens)
        
        p(S27)-G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
        
        Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
        
        PRKCH [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24723 PRKCH

Gene Names

PRKCH, PKCL, PRKCL

Chain

chain:1-683

Reference Genes

BioGPS Gene:5583 PRKCH

COSMIC (genes):PRKCH PRKCH

CTD Gene:5583 PRKCH

dbSNP Gene:5583 PRKCH

ENSEMBL:ENSG00000027075 PRKCH

HGNC:9403 PRKCH

KEGG:hsa:5583 PRKCH

Monarch:5583 PRKCH

NCBI Gene:5583 PRKCH

OMIM:605437 PRKCH

UCSC:P24723 PRKCH

Reference Transcript

Other Identifiers

11718809_a_at

11718810_at

11718811_s_at

1267_at

206099_PM_at

206099_at

218764_PM_at

218764_at

230124_PM_at

230124_at

3538876

3538877

3538894

3538895

3538896

3538899

3538900

3538905

3538906

3538907

3538908

3538909

3538910

3538937

3538939

3538951

3538953

3538954

3538956

3538957

3538958

3538959

3538961

3538962

3538963

3538964

3538978

3538979

3538983

3539009

3539010

3539011

3539012

3539013

3539014

3539020

3539024

3539025

3539026

3539027

3539028

3539034

3539037

5583

58935_s_at

75227_s_at

75586_r_at

7974835

A_14_P123460

A_14_P131273

A_23_P205567

A_32_P10165

GE57971

GE82784

GO:0003824

GO:0004672

GO:0004674

GO:0004697

GO:0004699

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006355

GO:0006468

GO:0007165

GO:0010744

GO:0016740

GO:0019899

GO:0030154

GO:0031267

GO:0034351

GO:0035556

GO:0036211

GO:0043226

GO:0045618

GO:0046872

GO:0050861

GO:0051092

GO:0060252

GO:0070062

GO:0070528

GO:0080090

GO:0106310

GO:0140096

GO:1903078

GO:2000810

HMNXSV003014530

Hs.144553.0.A1_3p_at

ILMN_1780898

M55284_at

PH_hs_0015962

TC14000371.hg

TC14001723.hg

g13129041_3p_at

g5453971_3p_at

Participates

as a candidate of

Keratinocyte PKCs [cytosol] (Homo sapiens)

as a member of

Protein kinase C, novel isoforms [cytosol] (Homo sapiens)

Inferred To

PRKCH [cytosol] (Bos taurus)

PRKCH [cytosol] (Caenorhabditis elegans)

PRKCH [cytosol] (Canis familiaris)

PRKCH [cytosol] (Danio rerio)

PRKCH [cytosol] (Dictyostelium discoideum)

PRKCH [cytosol] (Drosophila melanogaster)

PRKCH [cytosol] (Gallus gallus)

PRKCH [cytosol] (Mus musculus)

PRKCH [cytosol] (Rattus norvegicus)

PRKCH [cytosol] (Saccharomyces cerevisiae)

PRKCH [cytosol] (Schizosaccharomyces pombe)

Homologues of PRKCH [cytosol] (Dictyostelium discoideum)

Homologues of PRKCH [cytosol] (Schizosaccharomyces pombe)

Cross References

Guide to Pharmacology - Targets

1487

ENSEMBL

ENSP00000329127, ENSP00000450981, ENST00000332981, ENST00000555082, ENSG00000027075

OpenTargets

ENSG00000027075

ZINC - FDA approved

KPCL_HUMAN

ZINC - Substances

KPCL_HUMAN

ZINC - Biogenic

KPCL_HUMAN

ZINC target

P24723

PRO

P24723

PDB

2FK9, 8FP1, 8FP3, 3TXO

ZINC - Investigational

KPCL_HUMAN

ZINC - Metabolites

KPCL_HUMAN

IntEnz

2.7.11.13

GeneCards

PRKCH

HPA

ENSG00000027075-PRKCH

Pharos - Targets

P24723

ZINC - Predictions - Purchasable

KPCL_HUMAN

HMDB Protein

HMDBP01850

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17252 PRKCA	8	PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) p-T497-PRKCA [cytosol] (R-HSA-5218731) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.527	2

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