USP20, USP33 deubiquitinate ADRB2

Stable Identifier
R-HSA-5696968
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endosome membrane
ReviewStatus
5/5
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USP20, USP33 deubiquitinate ADRB2
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USP20 and USP33 act as a regulators of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of the beta-2 adrenergic receptor (ADRB2), prolonging agonist stimulation and inhibiting lysosomal trafficking (Berthouze et al. 2009).
Literature References
PubMed ID Title Journal Year
19424180 The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization

Berthouze, M, Venkataramanan, V, Li, Y, Shenoy, SK

EMBO J. 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type deubiquitinase activity of USP20,USP33:PolyUb-ADRB2 [endosome membrane]

Physical Entity
USP20,USP33:PolyUb-ADRB2 [endosome membrane] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
USP20, USP33 deubiquitinate ADRB2 (Bos taurus)
USP20, USP33 deubiquitinate ADRB2 (Canis familiaris)
USP20, USP33 deubiquitinate ADRB2 (Danio rerio)
USP20, USP33 deubiquitinate ADRB2 (Drosophila melanogaster)
USP20, USP33 deubiquitinate ADRB2 (Gallus gallus)
USP20, USP33 deubiquitinate ADRB2 (Mus musculus)
USP20, USP33 deubiquitinate ADRB2 (Rattus norvegicus)
USP20, USP33 deubiquitinate ADRB2 (Sus scrofa)
USP20, USP33 deubiquitinate ADRB2 (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-01)
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