USP20, USP33 deubiquitinate ADRB2

Stable Identifier
R-HSA-5696968
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP20 and USP33 act as a regulators of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of the beta-2 adrenergic receptor (ADRB2), prolonging agonist stimulation and inhibiting lysosomal trafficking (Berthouze et al. 2009).

Literature References
PubMed ID Title Journal Year
19424180 The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization

Berthouze, M, Venkataramanan, V, Li, Y, Shenoy, SK

EMBO J. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP20,USP33:PolyUb-ADRB2 [endosome membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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