USP47 deubiquitinates POLB

Stable Identifier
R-HSA-5696947
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP47 specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), increasing its stability and thereby playing a role in base-excision repair (Parsons et al. 2011).

Literature References
PubMed ID Title Journal Year
21362556 USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β

Kessler, BM, Edelmann, MJ, Dianov, GL, Parsons, JL, Khoronenkova, SV, Dianova, II

Mol. Cell 2011
Participants
Participates
Catalyst Activity

thiol-dependent deubiquitinase activity of USP47:PolyUb-POLB [nucleoplasm]

Orthologous Events
Authored
Reviewed
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