USP47 deubiquitinates POLB

Stable Identifier
R-HSA-5696947
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
USP47 deubiquitinates POLB
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

USP47 specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), increasing its stability and thereby playing a role in base-excision repair (Parsons et al. 2011).

Literature References
PubMed ID Title Journal Year
21362556 USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β

Kessler, BM, Edelmann, MJ, Dianov, GL, Parsons, JL, Khoronenkova, SV, Dianova, II

Mol. Cell 2011
Participants
Input
Output
Participates
as an event of
Catalyst Activity

thiol-dependent deubiquitinase activity of USP47:PolyUb-POLB [nucleoplasm]

Physical Entity
USP47:PolyUb-POLB [nucleoplasm] (Homo sapiens)
Activity
thiol-dependent deubiquitinase (GO:0004843)
Orthologous Events
USP47 deubiquitinates POLB (Canis familiaris)
USP47 deubiquitinates POLB (Danio rerio)
USP47 deubiquitinates POLB (Dictyostelium discoideum)
USP47 deubiquitinates POLB (Mus musculus)
USP47 deubiquitinates POLB (Rattus norvegicus)
USP47 deubiquitinates POLB (Sus scrofa)
USP47 deubiquitinates POLB (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-01)
Cite Us!