USP47 deubiquitinates POLB

Stable Identifier
R-HSA-5696947
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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USP47 deubiquitinates POLB
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USP47 specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), increasing its stability and thereby playing a role in base-excision repair (Parsons et al. 2011).

Literature References
PubMed ID Title Journal Year
21362556 USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β

Parsons, JL, Dianova, II, Khoronenkova, SV, Edelmann, MJ, Kessler, BM, Dianov, GL

Mol. Cell 2011
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of USP47:PolyUb-POLB [nucleoplasm]
Physical Entity
USP47:PolyUb-POLB [nucleoplasm]
Activity
thiol-dependent ubiquitin-specific protease activity (0004843)
Orthologous Events
USP47 deubiquitinates POLB (Canis familiaris)
USP47 deubiquitinates POLB (Danio rerio)
USP47 deubiquitinates POLB (Mus musculus)
USP47 deubiquitinates POLB (Rattus norvegicus)
USP47 deubiquitinates POLB (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-01)
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