Ubiquitination plays a key role in the regulation of signaling via TAK1 (Chen 2012). USP18 catalyzes the deubiquitination of the TAK1:TAB1 complex, reversing TAK1 activating ubiquitination, which restricts activation of NF-kappaB, NFAT and JNK and in decreases the expression of IL2 in T cells after TCR activation (Liu et al. 2013).
Tian, Q, Dong, C, Yan, M, Gorjestani, S, Liu, X, Zhang, DE, Li, H, Blonska, M, Lin, X, Zhong, B
cysteine-type deubiquitinase activity of USP18:PolyUb-MAP3K7:TAB1 [cytosol]
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