USP18 deubiquitinates TAK1:TAB1

Stable Identifier
R-HSA-5696534
Type
Reaction [transition]
Species
Homo sapiens
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Ubiquitination plays a key role in the regulation of signaling via TAK1 (Chen 2012). USP18 catalyzes the deubiquitination of the TAK1:TAB1 complex, reversing TAK1 activating ubiquitination, which restricts activation of NF-kappaB, NFAT and JNK and in decreases the expression of IL2 in T cells after TCR activation (Liu et al. 2013).

Literature References
PubMed ID Title Journal Year
23825189 USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex

Liu, X, Li, H, Zhong, B, Blonska, M, Gorjestani, S, Yan, M, Tian, Q, Zhang, DE, Lin, X, Dong, C

J. Exp. Med. 2013
Participants
Participates
Catalyst Activity

thiol-dependent deubiquitinase activity of USP18:PolyUb-MAP3K7:TAB1 [cytosol]

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