Reactome | AOC2 deaminates TYR

AOC2 deaminates TYR

Stable Identifier

R-HSA-5696146

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Retina-specific copper amine oxidase (AOC2) is present on the cell surface of most cells but especially retinal cells. It is classed as a semicarbazide-sensitive amine oxidase (SSAO) and catalyses the oxidative deamination of aromatic amines such as tyramine (TYR, shown here), 2-phenylethylamine and tryptamine (Kaitaniemi et al. 2009, Bour et al. 2007). Overexpression of AOC2 could result in tissue destruction seen in ocular pathologies.

Literature References

PubMed ID	Title	Journal	Year
19588076	The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase Kaitaniemi, S, Elovaara, H, Grön, K, Kidron, H, Liukkonen, J, Salminen, T, Salmi, M, Jalkanen, S, Elima, K	Cell. Mol. Life Sci.	2009
17400359	Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes Bour, S, Daviaud, D, Gres, S, Lefort, C, Prévot, D, Zorzano, A, Wabitsch, M, Saulnier-Blache, JS, Valet, P, Carpéné, C	Biochimie	2007