Retina-specific copper amine oxidase (AOC2) is present on the cell surface of most cells but especially retinal cells. It is classed as a semicarbazide-sensitive amine oxidase (SSAO) and catalyses the oxidative deamination of aromatic amines such as tyramine (TYR, shown here), 2-phenylethylamine and tryptamine (Kaitaniemi et al. 2009, Bour et al. 2007). Overexpression of AOC2 could result in tissue destruction seen in ocular pathologies.
Jalkanen, S, Elovaara, H, Grön, K, Salmi, M, Kaitaniemi, S, Elima, K, Liukkonen, J, Salminen, T, Kidron, H
Saulnier-Blache, JS, Lefort, C, Wabitsch, M, Valet, P, Gres, S, Carpéné, C, Zorzano, A, Prévot, D, Daviaud, D, Bour, S
primary amine oxidase activity of AOC2 [plasma membrane]
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