Reactome | LIPC dimer hydrolyses TAG to DAG and FA

LIPC dimer hydrolyses TAG to DAG and FA

Stable Identifier

R-HSA-5694109

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Fatty acids (FAs) are used as energy substrates and are stored as triglycerides. Triacylglycerol (TAG) has to be cleaved by lipases to be able to move in and out of cells for usage. Hepatic triacylglycerol lipase (LIPC) is one of several enzymes that catalyses the hydrolysis of TAGs to free fatty acids (FAs) and diacylglycerol (DAG) (Hegele et al. 1993, Santamarina-Fojo et al. 2004). Defects in LIPC can cause hepatic lipase deficiency (HL deficiency; MIM:614025), a disorder characterised by premature atherosclerosis and abnormal circulating lipoproteins (Hegele et al. 1992, 1993).

Literature References

PubMed ID	Title	Journal	Year
1301939	Human hepatic lipase mutations and polymorphisms Hegele, RA, Tu, L, Connelly, PW	Hum. Mutat.	1992
15284087	Hepatic lipase, lipoprotein metabolism, and atherogenesis Santamarina-Fojo, S, González-Navarro, H, Freeman, L, Wagner, E, Nong, Z	Arterioscler. Thromb. Vasc. Biol.	2004
8485124	Hepatic lipase deficiency. Clinical, biochemical, and molecular genetic characteristics Hegele, RA, Little, JA, Vezina, C, Maguire, GF, Tu, L, Wolever, TS, Jenkins, DJ, Connelly, PW	Arterioscler. Thromb.	1993