LIPC dimer hydrolyses TAG to DAG and FA

Stable Identifier
Reaction [transition]
Homo sapiens
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Fatty acids (FAs) are used as energy substrates and are stored as triglycerides. Triacylglycerol (TAG) has to be cleaved by lipases to be able to move in and out of cells for usage. Hepatic triacylglycerol lipase (LIPC) is one of several enzymes that catalyses the hydrolysis of TAGs to free fatty acids (FAs) and diacylglycerol (DAG) (Hegele et al. 1993, Santamarina-Fojo et al. 2004). Defects in LIPC can cause hepatic lipase deficiency (HL deficiency; MIM:614025), a disorder characterised by premature atherosclerosis and abnormal circulating lipoproteins (Hegele et al. 1992, 1993).

Literature References
PubMed ID Title Journal Year
1301939 Human hepatic lipase mutations and polymorphisms

Hegele, RA, Tu, L, Connelly, PW

Hum. Mutat. 1992
15284087 Hepatic lipase, lipoprotein metabolism, and atherogenesis

Nong, Z, Santamarina-Fojo, S, Freeman, L, Wagner, E, González-Navarro, H

Arterioscler. Thromb. Vasc. Biol. 2004
8485124 Hepatic lipase deficiency. Clinical, biochemical, and molecular genetic characteristics

Maguire, GF, Jenkins, DJ, Vezina, C, Hegele, RA, Wolever, TS, Tu, L, Connelly, PW, Little, JA

Arterioscler. Thromb. 1993
Catalyst Activity

triglyceride lipase activity of LIPC dimer:heparin [extracellular region]

Orthologous Events
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