Reactome | DUOX1 reduces O2 to H2O2

DUOX1 reduces O2 to H2O2

Stable Identifier

R-HSA-5693681

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Dual oxidase 1 (DUOX1) mediates the generation of hydrogen peroxide (H2O2) from oxygen and NADPH, which is required for the activity of thyroid peroxidase for thyroid hormone formation and lactoperoxidase. The NADPH oxidase activity requires the presence of calcium (Edens et al. 2001, Ameziane-El-Hassani et al. 2005). DUOX1 and DUOX2 have different activation pathways (Rigutto et al., 2009).

DUOX1/2 is part of the thyroxisome, a complex consisting of at least DUOX1/2, Dual oxidase maturation factor 1/2 (DUOXA1/2)(Grasberger & Refetoff, 2006), Thyroid peroxidase (TPO)(Fortunato et al., 2010) and Thioredoxin domain-containing protein 11 (TXNDC11, EFP1)(Wang et al., 2005), which is bound to Caveolin-1 (CAV1)(Senou et al., 2009) structures on the extracellular side of the apical plasma membrane of thyroid cells (reviewed in Jing & Zhang, 2022).

Literature References

PubMed ID	Title	Journal	Year
15561711	Identification of a novel partner of duox: EFP1, a thioredoxin-related protein Wang, D, De Deken, X, Milenkovic, M, Song, Y, Pirson, I, Dumont, JE, Miot, F	J Biol Chem	2005
19435853	Role of caveolin-1 in thyroid phenotype, cell homeostasis, and hormone synthesis: in vivo study of caveolin-1 knockout mice Senou, M, Costa, MJ, Massart, C, Thimmesch, M, Khalifa, C, Poncin, S, Boucquey, M, Gérard, AC, Audinot, JN, Dessy, C, Ruf, J, Feron, O, Devuyst, O, Guiot, Y, Dumont, JE, Van Sande, J, Many, MC	Am J Physiol Endocrinol Metab	2009
11514595	Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox Edens, WA, Sharling, L, Cheng, G, Shapira, R, Kinkade, JM, Lee, T, Edens, HA, Tang, X, Sullards, C, Flaherty, DB, Benian, GM, Lambeth, JD	J. Cell Biol.	2001
36187113	Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion Jing, L, Zhang, Q	Front Endocrinol (Lausanne)	2022
19144650	Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation Rigutto, S, Hoste, C, Grasberger, H, Milenkovic, M, Communi, D, Dumont, JE, Corvilain, B, Miot, F, De Deken, X	J Biol Chem	2009
15972824	Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity Ameziane-El-Hassani, R, Morand, S, Boucher, JL, Frapart, YM, Apostolou, D, Agnandji, D, Gnidehou, S, Ohayon, R, Noël-Hudson, MS, Francon, J, Lalaoui, K, Virion, A, Dupuy, C	J. Biol. Chem.	2005
20826581	Functional consequences of dual oxidase-thyroperoxidase interaction at the plasma membrane Fortunato, RS, Lima de Souza, EC, Ameziane-el Hassani, R, Boufraqech, M, Weyemi, U, Talbot, M, Lagente-Chevallier, O, de Carvalho, DP, Bidart, JM, Schlumberger, M, Dupuy, C	J Clin Endocrinol Metab	2010
16651268	Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent Grasberger, H, Refetoff, S	J Biol Chem	2006