PSMD14 cleaves K63-linked ubiquitin

Stable Identifier
R-HSA-5691431
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PSMD14 cleaves K63-linked ubiquitin
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PSMD14 (RPN11, POH1) is a subunit of the proteasomal 19S lid complex that specifically cleaves Lysine-63-linked polyubiquitin chains (Yao & Cohen 2002, Butler et al. 2012).
Literature References
PubMed ID Title Journal Year
12353037 A cryptic protease couples deubiquitination and degradation by the proteasome

Cohen, RE, Yao, T

Nature 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

K63-linked deubiquitinase activity of PSMD14 [cytosol]

Physical Entity
PSMD14 [cytosol] (Homo sapiens)
Activity
K63-linked deubiquitinase activity (GO:0061578)
Orthologous Events
PSMD14 cleaves K63-linked ubiquitin (Bos taurus)
PSMD14 cleaves K63-linked ubiquitin (Caenorhabditis elegans)
PSMD14 cleaves K63-linked ubiquitin (Canis familiaris)
PSMD14 cleaves K63-linked ubiquitin (Danio rerio)
PSMD14 cleaves K63-linked ubiquitin (Dictyostelium discoideum)
PSMD14 cleaves K63-linked ubiquitin (Drosophila melanogaster)
PSMD14 cleaves K63-linked ubiquitin (Gallus gallus)
PSMD14 cleaves K63-linked ubiquitin (Mus musculus)
PSMD14 cleaves K63-linked ubiquitin (Plasmodium falciparum)
PSMD14 cleaves K63-linked ubiquitin (Rattus norvegicus)
PSMD14 cleaves K63-linked ubiquitin (Saccharomyces cerevisiae)
PSMD14 cleaves K63-linked ubiquitin (Schizosaccharomyces pombe)
PSMD14 cleaves K63-linked ubiquitin (Sus scrofa)
PSMD14 cleaves K63-linked ubiquitin (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-05-07)
Cite Us!