BRCA1-A complex deubiquitinates K63polyUb-histone H2A

Stable Identifier
R-HSA-5691411
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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BRCC3 (BRCC36) as part of the BRCA1-A complex, antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks (Shao et al. 2009), specifically removing Lysine-63-linked polyubiquitin on histone H2A and H2AX. K63-linked polyubiquitination of H2A is induced by DNA damage and is required for the DNA repair response (Cao & Yan, 2012).

Literature References
PubMed ID Title Journal Year
19202061 The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

Shao, G, Lilli, DR, Patterson-Fortin, J, Coleman, KA, Morrissey, DE, Greenberg, RA

Proc. Natl. Acad. Sci. U.S.A. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Lys63-specific deubiquitinase activity of BRCA1-A Complex:K63polyUb-histone H2A [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created
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