Reactome | BRCA1-A complex deubiquitinates K63polyUb-histone H2A

BRCA1-A complex deubiquitinates K63polyUb-histone H2A

Stable Identifier

R-HSA-5691411

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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BRCA1-A complex deubiquitinates K63polyUb-histone H2A

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BRCC3 (BRCC36) as part of the BRCA1-A complex, antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks (Shao et al. 2009), specifically removing Lysine-63-linked polyubiquitin on histone H2A and H2AX. K63-linked polyubiquitination of H2A is induced by DNA damage and is required for the DNA repair response (Cao & Yan, 2012).

Literature References

PubMed ID	Title	Journal	Year
19202061	The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks Shao, G, Morrissey, DE, Coleman, KA, Patterson-Fortin, J, Greenberg, RA, Lilli, DR	Proc. Natl. Acad. Sci. U.S.A.	2009