Reactome | Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER

Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER

Stable Identifier

R-HSA-5690991

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ERCC1:ERCC4 (ERCC1:XPF) DNA endonuclease complex binds 5' to the DNA damage at global genome nucleotide excision repair (GG-NER) sites to form the incision complex. Binding of ERCC5 (XPG) to the NER site precedes the recruitment of ERCC1:ERCC4 (Riedl et al. 2003). ERCC1 directly interacts with XPA, and this interaction is necessary for the loading of ERCC1:ERCC4 to the open bubble structure in damaged dsDNA and the progression of GG-NER (Tsodikov et al. 2007, Orelli et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
19940136	The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways McClendon, TB, Orelli, B, Niedernhofer, LJ, Ellenberger, T, Schärer, OD, Tsodikov, OV	J. Biol. Chem.	2010
14517266	The comings and goings of nucleotide excision repair factors on damaged DNA Riedl, T, Egly, JM, Hanaoka, F	EMBO J.	2003
17948053	Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA Orelli, B, Shoshani, I, Wagner, G, Oberman, R, Ellenberger, T, Ivanov, D, Staresincic, L, Schärer, OD, Tsodikov, OV	EMBO J.	2007