ERCC1:ERCC4 (ERCC1:XPF) DNA endonuclease complex binds 5' to the DNA damage at global genome nucleotide excision repair (GG-NER) sites to form the incision complex. Binding of ERCC5 (XPG) to the NER site precedes the recruitment of ERCC1:ERCC4 (Riedl et al. 2003). ERCC1 directly interacts with XPA, and this interaction is necessary for the loading of ERCC1:ERCC4 to the open bubble structure in damaged dsDNA and the progression of GG-NER (Tsodikov et al. 2007, Orelli et al. 2010).
McClendon, TB, Orelli, B, Niedernhofer, LJ, Ellenberger, T, Schärer, OD, Tsodikov, OV
Riedl, T, Egly, JM, Hanaoka, F
Orelli, B, Shoshani, I, Wagner, G, Oberman, R, Ellenberger, T, Ivanov, D, Staresincic, L, Schärer, OD, Tsodikov, OV
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