LGI3 binds ADAM22,23,synatxin1

Stable Identifier
R-HSA-5682802
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Leucine-rich glioma inactivated 3 (LGI3) is a secreted protein and a member of LGI/epitempin family expressed in the peripheral nerve and interacts with ADAM22 and ADAM23 as well as syntaxin1 in the presynaptic SNARE complex. LGI3 is suggested to be involved in multiple functions. It induces neurite outgrowth and increases phosphorylation of the signal transduction proteins AKT and FAK (focal adhesion kinase) (Park et al. 2010). It appears to promote amyloid beta and synataxin1 endocytosis (Kimura et al. 2007, Okabayashi & Kimura 2008,2010).

Literature References
PubMed ID Title Journal Year
20461023 LGI3 interacts with flotillin-1 to mediate APP trafficking and exosome formation

Okabayashi, S, Kimura, N

Neuroreport 2010
18628660 Leucine-rich glioma inactivated 3 is involved in amyloid beta peptide uptake by astrocytes and endocytosis itself

Okabayashi, S, Kimura, N

Neuroreport 2008
17387609 Abeta upregulates and colocalizes with LGI3 in cultured rat astrocytes

Kimura, N, Ishii, Y, Suzaki, S, Negishi, T, Kyuwa, S, Yoshikawa, Y

Cell. Mol. Neurobiol. 2007
20162351 Leucine-rich glioma inactivated 3 induces neurite outgrowth through Akt and focal adhesion kinase

Park, WJ, Lim, YY, Kwon, NS, Baek, KJ, Kim, DS, Yun, HY

Neurochem. Res. 2010
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