Reactome | LGI3 binds ADAM22,23,synatxin1

LGI3 binds ADAM22,23,synatxin1

Stable Identifier

R-HSA-5682802

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Leucine-rich glioma inactivated 3 (LGI3) is a secreted protein and a member of LGI/epitempin family expressed in the peripheral nerve and interacts with ADAM22 and ADAM23 as well as syntaxin1 in the presynaptic SNARE complex. LGI3 is suggested to be involved in multiple functions. It induces neurite outgrowth and increases phosphorylation of the signal transduction proteins AKT and FAK (focal adhesion kinase) (Park et al. 2010). It appears to promote amyloid beta and synataxin1 endocytosis (Kimura et al. 2007, Okabayashi & Kimura 2008,2010).

Literature References

PubMed ID	Title	Journal	Year
18628660	Leucine-rich glioma inactivated 3 is involved in amyloid beta peptide uptake by astrocytes and endocytosis itself Okabayashi, S, Kimura, N	Neuroreport	2008
20461023	LGI3 interacts with flotillin-1 to mediate APP trafficking and exosome formation Okabayashi, S, Kimura, N	Neuroreport	2010
17387609	Abeta upregulates and colocalizes with LGI3 in cultured rat astrocytes Negishi, T, Suzaki, S, Ishii, Y, Kyuwa, S, Yoshikawa, Y, Kimura, N	Cell. Mol. Neurobiol.	2007
20162351	Leucine-rich glioma inactivated 3 induces neurite outgrowth through Akt and focal adhesion kinase Baek, KJ, Park, WJ, Yun, HY, Kwon, NS, Kim, DS, Lim, YY	Neurochem. Res.	2010