Reactome | ATG10:ATG12 binds ATG5

ATG10:ATG12 binds ATG5

Stable Identifier

R-HSA-5682010

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Nuclear magnetic resonance experiments, mutational analyses and crosslinking experiments show that ATG10 directly recognizes ATG5, binding it to place the side chain of ATG5 Lys-130 into an optimal orientation for its conjugation reaction with ATG12. ATG10 mediates the formation of the ATG12-ATG5 conjugate without a specific E3 enzyme (Yamaguchi et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22682742	Structural insights into Atg10-mediated formation of the autophagy-essential Atg12-Atg5 conjugate Yamaguchi, M, Noda, NN, Yamamoto, H, Shima, T, Kumeta, H, Kobashigawa, Y, Akada, R, Ohsumi, Y, Inagaki, F	Structure	2012
16963840	Stimulation of ATG12-ATG5 conjugation by ribonucleic acid Shao, Y, Gao, Z, Feldman, T, Jiang, X	Autophagy	2007