Reactome | Beclin-1 complex translocates to the ER

Beclin-1 complex translocates to the ER

Stable Identifier

R-HSA-5679266

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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The Beclin-1 complex (ATG14:PIK3C3:PIK3R4:BECN1) associates with the endoplasmic reticulum (ER). The ATG14 component of the complex contains an ER-binding motif in its N-terminal domain, which appears to be essential for its function in autophagy and for the recruitment of the other Beclin-1 complex subunits to the site of phagophore formation (Matsunaga et al. 2010). N-terminal myristoylation of the PIK3R4 (p150) component may also anchor the Beclin-1 complex to the membrane (Panaretou et al. 1997, Wirth et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
20713597	Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L Matsunaga, K, Morita, E, Saitoh, T, Akira, S, Ktistakis, NT, Izumi, T, Noda, T, Yoshimori, T	J. Cell Biol.	2010