ULK complex translocates to the ER

Stable Identifier
R-HSA-5679239
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The ULK complex is recruited to the membrane site of phagophore nucleation, which is likely to be a pre-existing ER structure containing the multi-membrane spanning protein vacuole membrane protein 1 (VMP1) (Wirth et al. 2013, Koyama-Honda et al. 2013). This may be mediated by the C-terminal early autophagy targeting/tethering (EAT) domain of ULK1, which appears to be essential for recruitment to the site of phagophore nucleation (Chan et al. 2009, Ragusa et al. 2012). The N-terminus of the ATG13 component of the ULK complex may also contribute to membrane association as it can interact with acidic phospholipids and is required for the translocation of ATG13 to omegasomes (Karanasios et al. 2013).

Literature References
PubMed ID Title Journal Year
23884233 Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site

Koyama-Honda, I, Itakura, E, Fujiwara, TK, Mizushima, N

Autophagy 2013
23727157 Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage

Wirth, M, Joachim, J, Tooze, SA

Semin. Cancer Biol. 2013
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed
Created