Reactome | MTMR14, MTMR3 dephosphorylate PI3P

MTMR14, MTMR3 dephosphorylate PI3P

Stable Identifier

R-HSA-5679206

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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MTMR14 (Jumpy) and MTMR3 are PI3P phosphatases that negatively regulate autophagosome formation by dephosphorylating PI3P on phagophores and autophagosomes (Vergne et al. 2009, Taguchi-Atarashi et al. 2010, Vergne & Deretic 2010).

Literature References

PubMed ID	Title	Journal	Year
19590496	Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy Deretic, V, Delgado, MA, Tosch, V, Roberts, E, Vergne, I, Proikas-Cezanne, T, Elmaoued, RA, Laporte, J	EMBO J.	2009
20059746	Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy Omori, H, Ktistakis, NT, Noda, T, Hamasaki, M, Taguchi-Atarashi, N, Matsunaga, K, Yoshimori, T	Traffic	2010