MTMR14, MTMR3 dephosphorylate PI3P

Stable Identifier
R-HSA-5679206
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MTMR14 (Jumpy) and MTMR3 are PI3P phosphatases that negatively regulate autophagosome formation by dephosphorylating PI3P on phagophores and autophagosomes (Vergne et al. 2009, Taguchi-Atarashi et al. 2010, Vergne & Deretic 2010).

Literature References
PubMed ID Title Journal Year
20059746 Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy

Taguchi-Atarashi, N, Hamasaki, M, Matsunaga, K, Omori, H, Ktistakis, NT, Yoshimori, T, Noda, T

Traffic 2010
19590496 Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy

Vergne, I, Roberts, E, Elmaoued, RA, Tosch, V, Delgado, MA, Proikas-Cezanne, T, Laporte, J, Deretic, V

EMBO J. 2009
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of MTMR3,MTMR14 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created