MTMR14, MTMR3 dephosphorylate PI3P

Stable Identifier
R-HSA-5679206
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MTMR14 (Jumpy) and MTMR3 are PI3P phosphatases that negatively regulate autophagosome formation by dephosphorylating PI3P on phagophores and autophagosomes (Vergne et al. 2009, Taguchi-Atarashi et al. 2010, Vergne & Deretic 2010).

Literature References
PubMed ID Title Journal Year
19590496 Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy

Deretic, V, Delgado, MA, Tosch, V, Roberts, E, Vergne, I, Proikas-Cezanne, T, Elmaoued, RA, Laporte, J

EMBO J. 2009
20059746 Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy

Omori, H, Ktistakis, NT, Noda, T, Hamasaki, M, Taguchi-Atarashi, N, Matsunaga, K, Yoshimori, T

Traffic 2010
Participants
Participates
Catalyst Activity

protein serine/threonine phosphatase activity of MTMR3,MTMR14 [cytosol]

Orthologous Events
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