WIPIs bind PI3P

Stable Identifier
R-HSA-5676229
Type
Reaction [binding]
Species
Homo sapiens
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WD repeat domain phospoinositide-interacting protein 2 (WIPI2) was identified as the mammalian homologue of yeast Atg18 (Polson et al. 2010). Like the other WIPI proteins, it binds PI(3,5)P2 and is recruited to autophagosomal membranes, especially upon autophagy induction (Proikas-Cezanne et al. 2015). WIPI1, WIPI2 and WIPI4 all localize to the initiating autophagosome during autophagy (Proikas-Cezanne et al. 2007, Obara et al. 2008, Polson et al. 2010). WIPI2 has been found to specifically bind to ATG16L1, thereby recruiting the ATG12:ATG5:ATG16L1 complex that is required for LC3 lipidation (Dooley et al. 2014).

Literature References
PubMed ID Title Journal Year
17618624 Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy

Proikas-Cezanne, T, Ruckerbauer, S, Stierhof, YD, Berg, C, Nordheim, A

FEBS Lett. 2007
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