Leucodopachrome, L-Dopaquinone transform to Dopachrome, L-Dopa

Stable Identifier
R-HSA-5672019
Type
Reaction [transition]
Species
Homo sapiens
Compartment
melanosome lumen
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Leucodopachrome, L-Dopaquinone transform to Dopachrome, L-Dopa
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A redox exchange between leucodopachrome (cyclodopa) and dopaquinone gives rise to dopachrome, an orange-red intermediate (Raper 1927, Mason et al. 1948) and dopa. This reaction is considered the source of dopa formed during melanogenesis (Ito & Wakamatsu 2008).

Literature References
PubMed ID Title Journal Year
18920770 The chemistry of melanin. III. Mechanism of the oxidation of dihydroxyphenylalanine by tyrosinase

Mason, HS

J. Biol. Chem. 1948
Participants
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Participant Of
hasEvent
Authored
Jupe, S  (2015-01-13)
Reviewed
Ito, S  (2015-02-13)
d'Ischia, M  (2015-02-13)
Created
Jupe, S  (2015-02-04)