Leucodopachrome, L-Dopaquinone transform to Dopachrome, L-Dopa

Stable Identifier
R-HSA-5672019
Type
Reaction [transition]
Species
Homo sapiens
Compartment
melanosome lumen
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Leucodopachrome, L-Dopaquinone transform to Dopachrome, L-Dopa
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A redox exchange between leucodopachrome (cyclodopa) and dopaquinone gives rise to dopachrome, an orange-red intermediate (Raper 1927, Mason et al. 1948) and dopa. This reaction is considered the source of dopa formed during melanogenesis (Ito & Wakamatsu 2008).

Literature References
PubMed ID Title Journal Year
18920770 The chemistry of melanin. III. Mechanism of the oxidation of dihydroxyphenylalanine by tyrosinase

Mason, HS

J. Biol. Chem. 1948
Participants
Input
Output
Participant Of
hasEvent
Authored
Jupe, S  (2015-01-13)
Reviewed
Ito, S  (2015-02-13)
d'Ischia, M  (2015-02-13)
Created
Jupe, S  (2015-02-04)
Cite Us!