Reactome | Activated CIT binds KIF14 and PRC1

Activated CIT binds KIF14 and PRC1

Stable Identifier

R-HSA-5671970

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Activated citron kinase (CIT) binds KIF14 and PRC1 at the central spindle and mid-body and this evolutionarily conserved interaction is necessary for the formation of the cleavage furrow and completion of cytokinesis. The C-terminal part of the CIT coiled-coil domain binds RHO GTPase while the N-terminal part of the CIT coiled coil domain binds KIF14 (Gruneberg et al. 2006, Watanabe et al. 2013, Bassi et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23716662	Citron kinase controls a molecular network required for midbody formation in cytokinesis Bassi, ZI, D'Avino, PP, Riparbelli, MG, Audusseau, M, Callaini, G	Proc. Natl. Acad. Sci. U.S.A.	2013
23444367	Citron kinase mediates transition from constriction to abscission through its coiled-coil domain Narumiya, S, Ishizaki, T, De Zan, T, Watanabe, S	J. Cell. Sci.	2013
16431929	KIF14 and citron kinase act together to promote efficient cytokinesis Chalamalasetty, RB, Neef, R, Barr, FA, Nigg, EA, Chan, EH, Gruneberg, U, Li, X	J. Cell Biol.	2006