Activated CIT binds KIF14 and PRC1

Stable Identifier
R-HSA-5671970
Type
Reaction
Species
Homo sapiens
Compartment
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Activated citron kinase (CIT) binds KIF14 and PRC1 at the central spindle and mid-body and this evolutionarily conserved interaction is necessary for the formation of the cleavage furrow and completion of cytokinesis. The C-terminal part of the CIT coiled-coil domain binds RHO GTPase while the N-terminal part of the CIT coiled coil domain binds KIF14 (Gruneberg et al. 2006, Watanabe et al. 2013, Bassi et al. 2013).

Literature References
PubMed ID Title Journal Year
23716662 Citron kinase controls a molecular network required for midbody formation in cytokinesis

Bassi, ZI, D'Avino, PP, Riparbelli, MG, Audusseau, M, Callaini, G

Proc. Natl. Acad. Sci. U.S.A. 2013
23444367 Citron kinase mediates transition from constriction to abscission through its coiled-coil domain

Narumiya, S, Ishizaki, T, De Zan, T, Watanabe, S

J. Cell. Sci. 2013
16431929 KIF14 and citron kinase act together to promote efficient cytokinesis

Chalamalasetty, RB, Neef, R, Barr, FA, Nigg, EA, Chan, EH, Gruneberg, U, Li, X

J. Cell Biol. 2006
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