PAK1 phosphorylates FLNA

Stable Identifier
R-HSA-5669250
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PAK1 phosphorylates FLNA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated PAK1 phosphorylates FLNA (filamin A) on serine residue S2152 in vitro and in vivo. FLNA is involved in PAK1-induced formation of membrane ruffles (Vadlamudi et al. 2002).
Literature References
PubMed ID Title Journal Year
12198493 Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1

Stossel, TP, Li, F, Kumar, R, Vadlamudi, RK, Nguyen, D, Ohta, Y, Adam, L

Nat. Cell Biol. 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S144,T423-PAK1:FLNA [cytosol]

Physical Entity
p-S144,T423-PAK1:FLNA [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
PAK1 phosphorylates FLNA (Bos taurus)
PAK1 phosphorylates FLNA (Caenorhabditis elegans)
PAK1 phosphorylates FLNA (Canis familiaris)
PAK1 phosphorylates FLNA (Dictyostelium discoideum)
PAK1 phosphorylates FLNA (Drosophila melanogaster)
PAK1 phosphorylates FLNA (Mus musculus)
PAK1 phosphorylates FLNA (Rattus norvegicus)
PAK1 phosphorylates FLNA (Sus scrofa)
PAK1 phosphorylates FLNA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-02-02)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-31)
Cite Us!