PAK1 phosphorylates FLNA

Stable Identifier
R-HSA-5669250
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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PAK1 phosphorylates FLNA
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Activated PAK1 phosphorylates FLNA (filamin A) on serine residue S2152 in vitro and in vivo. FLNA is involved in PAK1-induced formation of membrane ruffles (Vadlamudi et al. 2002).

Literature References
PubMed ID Title Journal Year
12198493 Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1

Vadlamudi, RK, Li, F, Adam, L, Nguyen, D, Ohta, Y, Stossel, TP, Kumar, R

Nat. Cell Biol. 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S144,T423-PAK1:FLNA [cytosol]
Physical Entity
p-S144,T423-PAK1:FLNA [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
PAK1 phosphorylates FLNA (Bos taurus)
PAK1 phosphorylates FLNA (Canis familiaris)
PAK1 phosphorylates FLNA (Danio rerio)
PAK1 phosphorylates FLNA (Mus musculus)
PAK1 phosphorylates FLNA (Rattus norvegicus)
PAK1 phosphorylates FLNA (Sus scrofa)
PAK1 phosphorylates FLNA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-02-02)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-31)