RAC1:GTP binds NOX3 complex

Stable Identifier
R-HSA-5668735
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Activated RAC1 (RAC1:GTP) binds to the NADPH oxidase NOX3 complex, consisting of NOX3, CYBA (p22phox), NCF1 (p47phox) and NCF2 (p67phox) or NOXA1. RAC1 directly interacts with a conserved region of NOX3 and with tetratricopeptide repeats of NCF2 or NOXA1 (Ueyama et al. 2006, Miyano and Sumimoto 2007, Kao et al. 2008).

Literature References
PubMed ID Title Journal Year
18347018 Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism

Kao, YY, Gianni, D, Bohl, B, Taylor, RM, Bokoch, GM

J. Biol. Chem. 2008
16507994 Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases

Ueyama, T, Geiszt, M, Leto, TL

Mol. Cell. Biol. 2006
17583407 Role of the small GTPase Rac in p22phox-dependent NADPH oxidases

Miyano, K, Sumimoto, H

Biochimie 2007
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