Reactome | NIK autophosphorylates on T559

NIK autophosphorylates on T559

Stable Identifier

R-HSA-5668545

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Signal-induced NIK accumulation and activation is likely an essential step for triggering the downstream signalling events in non-canonical NF-kB pathway. Like other MAP3Ks NIK may also be triggered by its phosphorylation. It has been suggested that threonine (T559) phosphorylation of NIK is required for its activity. T559 phosphorylation of NIK is likely mediated by autophosphorylation, which could be triggered through NIK accumulation (Lin et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9742107	Molecular determinants of NF-kappaB-inducing kinase action Lin, X, Mu, Y, Cunningham, ET, Marcu, KB, Geleziunas, R, Greene, WC	Mol. Cell. Biol.	1998