CDC42:GTP recruits DIAPH2-2 to kinetochores

Stable Identifier
R-HSA-5666129
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated CDC42 (CDC42:GTP) can localize to kinetochores of metaphase cells and recruit DIAPH2 transcriptional isoform DIAPH2-2 (DIA-12C, mDia3) to kinetochores. The CDC42:GTP:DIAPH2-2 complex regulates the attachment of microtubules to kinetochores (Yasuda et al. 2004).

Literature References
PubMed ID Title Journal Year
15085137 Cdc42 and mDia3 regulate microtubule attachment to kinetochores

Yasuda, S, Oceguera-Yanez, F, Kato, T, Okamoto, M, Yonemura, S, Terada, Y, Ishizaki, T, Narumiya, S

Nature 2004
Participants
Participant Of
Orthologous Events
Authored
Created