CDC42:GTP recruits DIAPH2-2 to kinetochores

Stable Identifier
R-HSA-5666129
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CDC42:GTP recruits DIAPH2-2 to kinetochores
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated CDC42 (CDC42:GTP) can localize to kinetochores of metaphase cells and recruit DIAPH2 transcriptional isoform DIAPH2-2 (DIA-12C, mDia3) to kinetochores. The CDC42:GTP:DIAPH2-2 complex regulates the attachment of microtubules to kinetochores (Yasuda et al. 2004).
Literature References
PubMed ID Title Journal Year
15085137 Cdc42 and mDia3 regulate microtubule attachment to kinetochores

Yasuda, S, Oceguera-Yanez, F, Kato, T, Okamoto, M, Yonemura, S, Terada, Y, Ishizaki, T, Narumiya, S

Nature 2004
Participants
Input
Output
Participates
as an event of
Orthologous Events
CDC42:GTP recruits DIAPH2-2 to kinetochores (Bos taurus)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Canis familiaris)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Gallus gallus)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Rattus norvegicus)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Sus scrofa)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-21)
Cite Us!