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Activated FGFR2 mutants:p-FRS2
Stable Identifier
R-HSA-5655236
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR2 in disease (Homo sapiens)
Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants phosphorylate FRS2 (Homo sapiens)
Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)
Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
21666749
Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
PLoS One
2011
21160078
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
Sci Transl Med
2010
Participants
components
Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
p-6Y-FRS2 [plasma membrane] (Homo sapiens)
Participant Of
input
Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
hasComponent
Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]
FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
output
Activated FGFR2 mutants phosphorylate FRS2
Disease
Name
Identifier
Synonyms
bone development disease
0080006
cancer
162
malignant tumor, malignant neoplasm, primary cancer
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