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MonoUb:K164-PCNA:RPA:RFC [nucleoplasm]
Stable Identifier
R-HSA-5651997
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Monoubiquitinylated PCNA-Replication Complex
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
USP1:WDR48 binds monoUb:K164-PCNA (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:USP1:WDR48:Damaged DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:USP1:WDR48:Damaged DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
Termination of translesion DNA synthesis (Homo sapiens)
TRIM25 binds monoUb:164-PCNA (Homo sapiens)
DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
UBE2L6:TRIM25:DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Homo sapiens)
UBE2L6:TRIM25:DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
Translesion Synthesis by POLH (Homo sapiens)
Elongation by POLH (Homo sapiens)
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
Insertion of correct bases opposite the lesion by POLH (Homo sapiens)
POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
SPRTN binds monoUb:K164-PCNA associated with POLH (Homo sapiens)
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Homo sapiens)
NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Homo sapiens)
NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
Translesion synthesis by POLI (Homo sapiens)
POLI incorporates dNMP opposite to damaged DNA base (Homo sapiens)
POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
POLZ elongates POLI-incorporated dNMP (Homo sapiens)
POLI:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T-mispaireddNMPs)-DNA Template,(Gamma-HOPdG:C-mispaireddNMPs)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:(EtAD:T-mispaireddNMPs)-DNA Template,(Gamma-HOPdG:C-mispaireddNMPs)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
Translesion synthesis by POLK (Homo sapiens)
POLK and POLZ cooperate in elongation of mispaired primer termini (Homo sapiens)
POLK:MonoUb:K164-PCNA:RPA:RFC:(Tg:A-mispaireddNMPs)-DNA Template,(OGUA:A-mispaireddNMPs)-DNA Template,(BPDE-G:C-mispaireddNMPs)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:(Tg:A-mispaireddNMPs)-DNA Template,(OGUA:A-mispaireddNMPs)-DNA Template,(BPDE-G:C-mispaireddNMPs)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
POLK incorporates dNMP opposite to damaged DNA base (Homo sapiens)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
Translesion synthesis by REV1 (Homo sapiens)
POLZ extends translesion synthesis (Homo sapiens)
POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt-mispairedPolydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
REV1 binds AP-dsDNA (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
REV1 inserts dCMP opposite to AP sites in DNA (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
REV1 recruits POLZ to (AP:Cyt)-DNA Template (Homo sapiens)
POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
D-loop extension by DNA polymerases (Homo sapiens)
PCNA:POLD,POLE,POLH,POLK:RPA:RFC [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:POLH,POLK [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Homo sapiens)
Participants
components
MonoUb:K164-PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer [nucleoplasm] (Homo sapiens)
RPA heterotrimer [nucleoplasm] (Homo sapiens)
Participant Of
hasComponent
DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm]
MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm]
MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm]
MonoUb:K164-PCNA:RPA:RFC:(EtAD:T-mispaireddNMPs)-DNA Template,(Gamma-HOPdG:C-mispaireddNMPs)-DNA Template [nucleoplasm]
MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm]
MonoUb:K164-PCNA:RPA:RFC:(Tg:A-mispaireddNMPs)-DNA Template,(OGUA:A-mispaireddNMPs)-DNA Template,(BPDE-G:C-mispaireddNMPs)-DNA Template [nucleoplasm]
MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm]
MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm]
MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm]
MonoUb:K164-PCNA:RPA:RFC:POLH,POLK [nucleoplasm]
MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm]
MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm]
NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA [nucleoplasm]
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm]
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt-mispairedPolydNMP)-DNA Template [nucleoplasm]
Inferred To
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Canis familiaris)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Danio rerio)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Gallus gallus)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Mus musculus)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Rattus norvegicus)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Saccharomyces cerevisiae)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Sus scrofa)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Xenopus tropicalis)
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