The N-terminal portion of MDM2 binds the N-terminal transactivation domain of TP53 (p53) and inhibits transcriptional transactivation by TP53 (Momand et al. 1992, Oliner et al. 1992, Oliner et al. 1993, Chen et al. 1993).
Meltzer, PS, Vogelstein, B, George, DL, Kinzler, KW, Oliner, JD
Chen, L, Chen, J, Cheng, Q, Li, B, Cross, B, Li, Z
Linares, LK, Scheffner, M, Hengstermann, A, Muller, S, Ciechanover, A
Levine, AJ, Chen, J, Marechal, V
Levine, AJ, Olson, DC, Zambetti, GP, George, D, Momand, J
Gyuris, J, Vogelstein, B, Pietenpol, JA, Kinzler, KW, Oliner, JD, Thiagalingam, S
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