Reactome | MDM2 binds TP53

MDM2 binds TP53

Stable Identifier

R-HSA-5633460

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Stabilization of p53 (Homo sapiens)
        
        MDM2 binds TP53 (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        MDM2 binds TP53 (Homo sapiens)

General

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SVG | | PPTX | SBGN

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The N-terminal portion of MDM2 binds the N-terminal transactivation domain of TP53 (p53) and inhibits transcriptional transactivation by TP53 (Momand et al. 1992, Oliner et al. 1992, Oliner et al. 1993, Chen et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
21986495	Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage Cheng, Q, Cross, B, Li, B, Chen, L, Li, Z, Chen, J	Mol. Cell. Biol.	2011
1614537	Amplification of a gene encoding a p53-associated protein in human sarcomas Oliner, JD, Kinzler, KW, Meltzer, PS, George, DL, Vogelstein, B	Nature	1992
14507994	HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53 Linares, LK, Hengstermann, A, Ciechanover, A, Muller, S, Scheffner, M	Proc. Natl. Acad. Sci. U.S.A.	2003
7686617	Mapping of the p53 and mdm-2 interaction domains Chen, J, Marechal, V, Levine, AJ	Mol. Cell. Biol.	1993
1535557	The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation Momand, J, Zambetti, GP, Olson, DC, George, D, Levine, AJ	Cell	1992
8479525	Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 Oliner, JD, Pietenpol, JA, Thiagalingam, S, Gyuris, J, Kinzler, KW, Vogelstein, B	Nature	1993

Participants

Input

Output

p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

This event is regulated

Negatively by

PHF20 [nucleoplasm]

Orthologous Events

MDM2 binds TP53 (Bos taurus)

MDM2 binds TP53 (Danio rerio)

MDM2 binds TP53 (Drosophila melanogaster)

MDM2 binds TP53 (Mus musculus)

MDM2 binds TP53 (Rattus norvegicus)

MDM2 binds TP53 (Sus scrofa)

MDM2 binds TP53 (Xenopus tropicalis)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2014-10-31)