Reactome | MDM2 binds TP53

MDM2 binds TP53

Stable Identifier

R-HSA-5633460

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Stabilization of p53 (Homo sapiens)
        
        MDM2 binds TP53 (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        MDM2 binds TP53 (Homo sapiens)

General

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The N-terminal portion of MDM2 binds the N-terminal transactivation domain of TP53 (p53) and inhibits transcriptional transactivation by TP53 (Momand et al. 1992, Oliner et al. 1992, Oliner et al. 1993, Chen et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
1614537	Amplification of a gene encoding a p53-associated protein in human sarcomas Oliner, JD, Kinzler, KW, Meltzer, PS, George, DL, Vogelstein, B	Nature	1992
21986495	Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage Cheng, Q, Cross, B, Li, B, Chen, L, Li, Z, Chen, J	Mol. Cell. Biol.	2011
14507994	HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53 Linares, LK, Hengstermann, A, Ciechanover, A, Muller, S, Scheffner, M	Proc. Natl. Acad. Sci. U.S.A.	2003
7686617	Mapping of the p53 and mdm-2 interaction domains Chen, J, Marechal, V, Levine, AJ	Mol. Cell. Biol.	1993
1535557	The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation Momand, J, Zambetti, GP, Olson, DC, George, D, Levine, AJ	Cell	1992
8479525	Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 Oliner, JD, Pietenpol, JA, Thiagalingam, S, Gyuris, J, Kinzler, KW, Vogelstein, B	Nature	1993