TP53 binds the RRM2B gene

Stable Identifier
R-HSA-5632887
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TP53 binds the RRM2B gene
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TP53 (p53) binds the p53-binding site in the first intron of RRM2B (p53R2) gene, which encodes a subunit of the ribonucleotide reductase complex (Tanaka et al. 2000). RRM2B is also regulated by TP73 (p73), a p53 family member (Nakano et al. 2000).
Literature References
PubMed ID Title Journal Year
10716435 A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

Tanaka, H, Arakawa, H, Yamaguchi, T, Shiraishi, K, Fukuda, S, Matsui, K, Takei, Y, Nakamura, Y

Nature 2000
10980602 A ribonucleotide reductase gene is a transcriptional target of p53 and p73

Nakano, K, Bálint, E, Ashcroft, M, Vousden, KH

Oncogene 2000
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Authored
Orlic-Milacic, M  (2014-12-23)
Reviewed
Hwang, PM  (2014-12-30)
Kang, JG  (2014-12-30)
Wang, PY  (2014-12-30)
Inga, A  (2016-02-04)
Zaccara, S  (2016-02-04)
Created
Orlic-Milacic, M  (2014-10-29)
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