TP53 binds the RRM2B gene

Stable Identifier
R-HSA-5632887
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TP53 (p53) binds the p53-binding site in the first intron of RRM2B (p53R2) gene, which encodes a subunit of the ribonucleotide reductase complex (Tanaka et al. 2000). RRM2B is also regulated by TP73 (p73), a p53 family member (Nakano et al. 2000).

Literature References
PubMed ID Title Journal Year
10980602 A ribonucleotide reductase gene is a transcriptional target of p53 and p73

Nakano, K, Bálint, E, Ashcroft, M, Vousden, KH

Oncogene 2000
10716435 A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

Tanaka, H, Arakawa, H, Yamaguchi, T, Shiraishi, K, Fukuda, S, Matsui, K, Takei, Y, Nakamura, Y

Nature 2000
Participants
Participant Of
Authored
Reviewed
Created