BRD7 promotes EP300 (p300)-mediated acetylation of TP53 on lysine residue K382, which enhances binding of TP53 to its target promoters. Also, BRD7 induces EP300-mediated acetylation of histone 3 on lysine residue K10 (also labeled in literature as K9), creating the H3K9 active chromatin mark at CDKN1A and MDM2 promoters (Drost et al. 2010), and possibly other TP53 promoters co-regulated by BRD7, such as SERPINE1, TIGAR, TNFRSF10C and NDRG1.
Tocco, F, Del Sal, G, Drost, J, Elkon, R, Holstege, H, Kerkhoven, R, Mantovani, F, Agami, R, Jonkers, J, Comel, A, Voorhoeve, PM
acetyltransferase activity of BRD7:p-S15,S20-TP53:EP300 [nucleoplasm]
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